注射用甲磺酸帕珠沙星在2种输液中的配伍稳定性考察  

Stability of Pazufloxacin Mesylate for Injection in Two Kinds of Infusions

作　　者：万正兰[1] 萧绮珊 佘子岳[1] 阮航[3] 

机构地区：[1]中山大学附属第五医院,珠海市519000 [2]广东中山市药品检验所,中山市528415 [3]广东药学院,广州市510006

出　　处：《中国药房》2009年第23期1788-1789,共2页China Pharmacy

摘　　要：目的:考察注射用甲磺酸帕珠沙星在2种输液中配伍的稳定性。方法:考察注射用甲磺酸帕珠沙星与果糖注射液、5%葡萄糖氯化钠注射液配伍后在12h内的外观及pH值变化,采用高效液相色谱法测定甲磺酸帕珠沙星的含量。结果:配伍液12h内外观、pH值及含量均无明显变化。结论:注射用甲磺酸帕珠沙星与果糖注射液、5%葡萄糖氯化钠注射液配伍12h内稳定。OBJECTIVE： To study the stability of Pazufloxacin Mesylate for Injection in two kinds of infusions. METHODS： The change of Pazufloxacin Mesylate for Injection in the appearance and the pH value within 12 h after mixing with fructose injection or 5% glucose and sodium chloride injection were investigated and the content of Pazufloxacin Mesylate was determined by HPLC. RESULTS： There was little change for the mixture in appearance, pH value and the content of Pazufloxacin Mesylate within 12 h. CONCLUSION： Pazufloxacin Mesylate for injection is stable within 12 h after mixing with Fructose injection or 5% Glucose and sodium chloride injection.

关 键 词：甲磺酸帕珠沙星 果糖注射液 5%葡萄糖氯化钠注射液 配伍 高效液相色谱法 稳定性 

分 类 号：R969.2[医药卫生—药理学] R978.1[医药卫生—药学]