^99Tcm-聚合白蛋白肺灌注显像对肺栓塞溶栓疗效的评价  

Evaluation of ^99Tcm-macroaggregated albumin pulmonary perfusion imaging to thrombolytic therapy in pulmonary embolism

作　　者：董华[1] 

机构地区：[1]天津医科大学第二医院核医学科,300211

出　　处：《国际放射医学核医学杂志》2009年第2期76-79,共4页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：目的 探讨^99Tcm-聚合白蛋白（^99Tcm-MAA）肺灌注显像评价肺栓塞溶栓治疗的价值。方法对54例急性肺栓塞的患者进行回顾性分析，所有患者均由^99Tcm-MAA肺灌注显像结合X线胸片检查确诊，并于溶栓治疗1周后复查肺灌注显像，部分病例于治疗3个月后再次复查。结果54例急性肺栓塞患者溶拴治疗前^99Tcm-MAA肺灌注显像共观察到347个受损肺段，X线胸片均无相应肺段或亚肺段异常。溶栓治疗后1周复查肺灌注显像，164个受损肺段（47．3％）恢复正常；3个月后再次复查，199个受损肺段（57．4％）恢复正常（χ^2=10．68，P〈0．05）。结论^99Tcm-MAA肺灌注显像是一种无创的诊断方法，对肺栓塞溶栓治疗效果的评估有重要价值。Objective To investigate the role of ^99Tcm-macroaggregated albumin （^99Tcm-MAA） pulmonary perfusion imaging in evaluating thrombolytic therapy in pulmonary embolism. Methods Date of 54 patients with acut pulmonary embolism diagnosed by ^99Tcm-MAA pulmonary perfusion imaging combined with radiography were analyzed retrospectively. Among them, pulmonary perfusion imaging was also performed one week after thrombolytic therapy. In some cases, pulmonary perfusiou imaging was performed three months after thrombolytic therapy. Results The results of radiography were normal in all cases, among 347 abnormal pulmonary segments in 54 cases. 164 （47.3%） and 199 （57.4%） segments were restored to normal 1 week and 3 months later（χ2=10.68, P〈0.05）. Conclusion As a non-invasive diagnostic method, ^99Tcm-MAA pulmonary perfusion imaging play an important role in evaluating the therapeutic effectiveness of thrombolytic therapy in patients with pulmonary embolism.

关 键 词：肺栓塞 99m锝聚合白蛋白 放射摄影术 胸廓 栓塞 治疗性 

分 类 号：R563.5[医药卫生—呼吸系统] R735.7[医药卫生—内科学]