腺苷负荷脑灌注显像安全性研究  

Safety of adenosine in stress cerebral perfusion imaging

作　　者：胡鹏程[1] 顾宇参[1] 刘文官[1] 修雁[1] 朱玮珉[1] 陈曙光[1] 石洪成[1] 

机构地区：[1]复旦大学附属中山医院核医学科,上海200032

出　　处：《国际放射医学核医学杂志》2009年第2期83-85,共3页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：教育部留学回国人员科研启动基金资助项目

摘　　要：目的 评价腺苷负荷脑血流灌注显像的安全性。方法 以腺苷负荷作为介入手段，按照常规腺苷负荷心肌灌注显像的方式，对80例脑病患者进行隔日法静息和负荷脑血流灌注显像。观察、记录患者在负荷过程前、中、后的主观、客观不良反应。结果 80例患者中没有发现因不良反应而提前终止或延长负荷显像的病例。有46例（58％）出现不同程度轻微不良反应。其主要症状包括头晕20例（25％）、心悸12例（15％）、低血压1例（1％）、气短7例（9％）、发热4例（5％）、出汗3例（4％）、恶心4例（5％）、皮肤潮红6例（8％）、胸部不适19例（24％）、腹部不适6例（8％）、味觉异常3例（4％）、口干1例（1％）。只有1例出现ST段轻度压低心电图改变。结论腺苷负荷脑血流灌注显像安全性好，不良反应轻微。Objective To evaluate the safety of adenosine as pharmacological stress agents in stress cerebral perfusion imaging. Methods Eighty patients under investigation for suspected cerebral vessel disease were recruited. Each had a resting scan and a stress scan on different days. The adenosine stress protocol was as same as the protocol used in adenosine stress myocardial perfusion imaging. Subjective and objective side-effects were investigated during pharmacological stress procedure. Results All patients completed the 6 min infusion protocol without premature termination on safety criteria or due to intolerable symptoms. 46 patients had mild side effects. 20 patients （25%） had dizziness, 12 patients （15%） had palpitation, 1 patient （1%） was hypotensive, 7 patients （9%） had dyspnoea, 4 patients （5%） felt hot, 3 patients （4%） had sweat, 4 patients （5%） had nausea, 6 patients （8%） had flushing, 19 patients （24%） had chest pain, 6 patients （8%） had abdomen pain, 3 patients （4%） had abnormal taste and 1 patient （1%） were thirsty. Transient ST change occurred in only 1 patient. Conclusion Adenosine stress cerebral perfusion imaging is a safe diagnostic method with mild side effects.

关 键 词：腺苷 脑 体层摄影术 发射型计算机 单光子 99m-双半胱乙酯 

分 类 号：R817.4[医药卫生—影像医学与核医学]