血清β-人绒毛膜促性腺激素、孕酮、雌二醇值对早期正常妊娠、妊娠流产和异位妊娠的诊断价值  

Diagnostic value of serum β-human chorionic gonadotropin, progesterone and estradiol in early normal pregnancy, pregnancy abortion and ectopic pregnancy

作　　者：刘义明[1] 叶爱霞[1] 钟娆霞[1] 莫伟[1] 高卉[2] 

机构地区：[1]广东医学院第二附属医院检验科,湛江524003 [2]广东医学院第二附属医院妇产科,湛江524003

出　　处：《国际放射医学核医学杂志》2009年第2期102-104,共3页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：目的动态分析血清β-人绒毛膜促性腺激素（β-HCG）、孕酮和雌二醇值在鉴别早期正常妊娠、宫内妊娠流产和异位妊娠中的价值。方法将怀孕30～35d的106例受检者根据妊娠后果分为3组：正常妊娠（先兆流产继续妊娠）组38例，宫内妊娠流产组33例，异位妊娠组35例，采静脉血测定β-HCG、孕酮、雌二醇的水平，48h后用同法复测三项指标。结果首测时正常妊娠组三项指标均明显高于妊娠流产组和异位妊娠组，而妊娠流产组和异位妊娠组比较，β-HCG、孕酮、雌二醇差异均无统计学意义。复测β-HCG、孕酮、雌二醇，妊娠流产组孕酮值由（14．8±9．6）mg／L下降为（8．7±5．8）mg／L，下降显著，β-HCG、雌二醇差异无统计学意义；以复测β-HCG每48h升高〉60％为阳性、孕酮=20μg/L为阈值及两者联合分析鉴别正常妊娠和异常妊娠（妊娠流产和异位妊娠），有较好的敏感性、特异性和准确率；以复测β-HCG下降〉50％为阳性，孕酮=10μg/L为阈值及两者联合分析鉴别妊娠流产和异位妊娠，有较好的敏感性、特异性和准确率，两者联合分析确诊率更高。结论动态监测血清β-HCG、孕酮、雌二醇的水平及其升高和下降幅度，对鉴别早期正常妊娠、宫内妊娠流产和异位妊娠有一定的诊断价值。Objective Dynamic assay of serum β-human chorionic gonadotropin （β-HCG）, progesterone and estradiol value, in its analysis to identify early normal intrauterine pregnancy, abortion intrauterine pregnancy and ectopic pregnancy in value. Methods One hundred and six subject of pregnant 30-35 d of the patients were divided into three groups： early normal pregnancy group of 38 cases, early intrauterine pregnancy abortion group of 33 cases, ectopic pregnancy group of 35 cases. Determination to adopt blood β-HCG, progesterone, estradiol levels, 48 h with the law after the test of the three indicators. Results β-HCG, progesterone, estradiol of normal pregnancy group were significantly higher than the pregnancy abortion group and ectopic pregnancy group.β-HCG, progesterone, estradiol of pregnancy abortion group and eetopie pregnancy group in 30-35 d was no significant difference. Retest of β-HCG, progesterone, estradiol, pregnancy abortion group progesterone decreased from （14.8±9.6） μg/L to （8.7± 5.8）μg/L significantly and β-HCG, estradiol was no significant difference. To β-HCG test every 48 h increased〉 60% positive and progesterone=20μg/L as the threshold between the two and a joint analysis of three methods to identify normal pregnancy and abnormal pregnancy （ectopic pregnancy and pregnancy abortion）, there is a better sensitivity and specificity of diagnosis. In order to test β-HCG decline 〉50% positive and progesterone=10μg/L as the threshold between the two and a joint analysis of three methods to identify progesterone, estradiol pregnancy abortion and eetopic pregnancy, the better sensitivity and specificity of diagnosis, analysis of both the united confirmed a higher rate. Conclusion Dynamic monitoring of serum β-HCG, progesterone, estradiol have a certain value in early identification of the normal pregnancy, ectopic pregnancy and intrauterine pregnancy abortions.

关 键 词：绒毛膜促性腺激素 β亚单位 人 孕酮 雌二醇 妊娠 妊娠 异位 流产 自然 

分 类 号：R714.2[医药卫生—妇产科学] R446.1[医药卫生—临床医学]