162例妊娠肝内胆汁淤积症临床分析  

162 cases of intrahepatic cholestasis of pregnancy clinical analysis

作　　者：潘俐伶 

机构地区：[1]安徽省安庆市宜城医院妇产科,246001

出　　处：《中国实用医药》2009年第23期11-12,共2页China Practical Medicine

摘　　要：目的探讨2005年1月至2007年12月妊娠肝内胆汁淤积症(ICP)诊断及治疗以及对围产儿预后的影响。方法回顾分析本院2005年1月至2007年12月162例ICP诊治情况及围产儿结局。结果①诊断规范化,特别是胆酸升高为ICP的特异性指标,使ICP确诊时间提前,当胆酸升高>30μmol/L,羊水粪污率明显增加(P<0.01);②积极正确治疗,分娩方式以剖宫产分娩为主,虽剖宫产率增加,但产后出血率并未增加;③ICP发病率高,为9.35%,但胎儿宫内窘迫发生率未随之增加,新生儿窒息率低,围产儿发病率及病死率未增加。结论ICP发病率高,但诊断规范化,血清胆酸检查辅以肝功能检查,缩短确诊时间,积极正确治疗,分娩方式以剖宫产分娩为主,围产儿发病率及病死率未增加。Objective From January 2005 -2007 in December intrahepatic cholestasis of pregnancy （ICP）, as well as diagnosis and treatment of perinatal prognosis. Methods A retrospective analysis of our hospital in January 2005 -2007 in December diagnosis and treatment of 162 cases of ICP and perinatal outcome. Results （1）standardize the diagnosis, especially in acid increased the specific indicators for the ICP to ICP diagnosed earlier, when the acid increase 〉 30umol / L, a marked increase in amniotic fluid rate （P 〈0. 01 ） ; （2）actively proper treatment, delivery-oriented approach to cesarean section delivery, although the cesarean section rate increased, but did not increase the rate of postpartum hemorrhage; （3）ICP high incidence 9. 35%, but the incidence of fetal distress has not increased, the low rate of neonatal asphyxia, perinatal morbidity and mortality is not increased. Conclusion A high incidence of ICP, but the diagnosis of standardization, and serum bile acid by liver function tests to check to shorten the diagnosis time, and actively correct treatment, birthbased approach to cesarean section delivery, perinatal morbidity and morality rate did not increase.

关 键 词：妊娠期胆汁淤积症 诊治 围产儿预后 

分 类 号：R714.2[医药卫生—妇产科学]