伊维菌素HP-β-CD包合工艺的优化  

Optimization for preparation process of ivermectin enveloped with hydroxypropyl-β-cyclodextrin

作　　者：张海亮[1] 薛芬[1] 李引乾[1] 曹光荣[1] 梅雪洁[1] 庞利娜[1] 黄冻[1] 王婷[1] 赵力[1] 刘阳[1] 

机构地区：[1]西北农林科技大学动物医学院,陕西杨凌712100

出　　处：《畜牧与兽医》2009年第8期5-8,共4页Animal Husbandry & Veterinary Medicine

摘　　要：本文采用L9(34)正交试验,以伊维菌素利用率和增容倍数为指标,优选出伊维菌素-羟丙基-β-环糊精包合工艺的最佳条件。主要参数:伊维菌素与羟丙基-β-环糊精的物质量之比1∶3,包合时间2 h,研磨温度55℃。羟丙基-β-环糊精研磨时间是影响伊维菌素包合效果的主要因素。本试验为伊维菌素新制剂开发和临床应用提供试验依据。This article investigated an optimum process for enclosing ivennectin into hydroxypropyl-β-cyclodextrin by an orthogonal design of L9 （ 3^4 ） based on the indexes of the utilization and the inclusion. And the best process technology was as follows ： the ratio between ivermectin and hydroxypropyl-β-cyclodextrin was 1 ： 3 （ mol/mol ） ; enclosing temperature was 55 ℃ ; enclosing time was 2 hours. Consumption of HP-β-Cyclodextrin plays an adominant role in inclusion efficiency. The findings apply a trial base for the development of new formulations of ivermectin.

关 键 词：伊维菌素 羟丙基-Β-环糊精 包合物 正交试验 

分 类 号：S859.5[农业科学—临床兽医学]