氯吡格雷对胃肠道的损害及其防治  

Clopidogrel induced gastrointestinal damage and its prevention

作　　者：孙沂[1] 樊宏伟[2] 张振玉[1] 

机构地区：[1]南京医科大学附属南京第一医院消化科,江苏省南京市210006 [2]南京医科大学附属南京第一医院临床药理科,江苏省南京市210006

出　　处：《世界华人消化杂志》2009年第18期1849-1854,共6页World Chinese Journal of Digestology

摘　　要：氯吡格雷作为新型抗血小板药物,其应用于心脑血管疾病的治疗已逾十年.近来,随着质子泵抑制剂(PPI)在预防氯吡格雷相关的胃肠道损害中心血管事件发生率和死亡率的升高,氯吡格雷对胃肠道的损害及其防治引起了临床医师的广泛关注.本文就氯吡格雷临床应用现状、对胃肠道的损害及其防治策略作一综述.As a new anti-platelet medicine, it has been more than 10 years since clopidogrel was applied to treat cardiovascular and cerebrovascular diseases. Recently, the increasing incidence and mortality of cardiovascular events in preventing clopidogrel associated gastrointestinal damage with PPI have been attracting wide attention of clinicians. This article reviews the present clinical application of clopidogrel, clopidogrel-induced gastrointestinal damage and its prevention strategy.

关 键 词：氯吡格雷 胃肠道损害 防治 

分 类 号：R541.4[医药卫生—心血管疾病]