新型噻吩席夫碱及其酯化产物合成与性能  

Synthesis and Property of New Thiophene Schiff Base and Its Esterifying Product

作　　者：韩相恩[1] 屈琦超[1] 吴玉彬[1] 徐延良[1] 韩辉[1] 

机构地区：[1]兰州交通大学化学与生物工程学院,兰州730070

出　　处：《应用化学》2009年第8期935-938,共4页Chinese Journal of Applied Chemistry

基　　金：甘肃省自然科学基金(3Z-S042-B25-041);兰州交通大学青蓝基金(QL-05-17A)资助项目

摘　　要：以噻吩为起始原料,优化了合成噻吩-2-甲醛的工艺,并由噻吩-2-甲醛与4-氨基苯酚缩合反应生成了噻吩-2-甲醛缩4-氨基苯酚席夫碱,用纸片法测试了该席夫碱有较好的抑菌作用,进一步由N,N-二环己基碳酰亚胺(DCC)/4-二甲氨基吡啶(DMAP)高效酯化法与十一烯酸进行酯化反应,通过偏光显微镜测得酯化产物有较好的液晶相织构。Thiophene-2-carbaldehyde was synthesized from thiophene under the optimized conditions.The product was used to synthesize Schiff base thiophene-2-carbaldehyde by reaction with 4-aminophenol.The thiophene Schiff base was esterified with undecene acid catalyzed by N,N′-dicyclohexylcarbodiimide（DCC）/4-dimethylamiopryidine（DMAP）.The structures and liquid crystalline properties of the synthesized compounds were investigated by IR,NMR,and the polarizing optical microscopy（POM）.The inhibiting activity of the thiophene Schiff base was tested with the paper strip method,and it displays a good inhibiting activity.

关 键 词：噻吩 席夫碱 抑菌作用 液晶 

分 类 号：O621.2[理学—有机化学]