一种类风湿因子血液净化吸附剂的制备与性能评价  

Preparation and Evaluation of an Adsorbent for Rheumatoid Factors

作　　者：王为超[1] 胡月晗[1] 欧来良[1] 孔德领[1] 俞耀庭[1] 

机构地区：[1]南开大学生物活性材料教育部重点实验室,天津300071

出　　处：《中国生物医学工程学报》2009年第4期561-566,共6页Chinese Journal of Biomedical Engineering

基　　金：天津市科技发展计划项目(YFSZSF00800)

摘　　要：研究的目的是制备一种吸附剂用于清除患者血液中大量的类风湿因子,并对制备的吸附剂进行吸附性能评价。首先制备了大孔聚乙烯醇微球载体,经活化后固定苯丙氨酸作为配基形成类风湿因子吸附剂,通过体外静态和动态吸附实验对其吸附性能以及相关的影响因素做系统的评价。结果表明,该吸附剂能够在短时间内快速吸附类风湿因子,具有较高的吸附效率(约60%)和吸附容量(750 IU/mL),适宜用作血液灌流去除类风湿因子的吸附剂。In order to removal high levels of rheumatoid factors（RFs） from the blood of rheumatoid arthritis patients, macroporous polyvinyl alcohol microspheres was prepared and activated, L-phenylalanine was immobilized as ligand to the beads to form the adsorbent. The adsorption performance of the adsorbent was evaluated in vitro by the static and circulation adsorption methods. The results showed that this kind of adsorbent could remove RFs rapidly and had an excellent adsorption percentage （about 60%）, high adsorption capacity （750 IU/mL）, being suitable for haemoperfusion to remove rheumatoid factors.

关 键 词：类风湿因子 血液灌流 吸附剂 聚乙烯醇微球 苯丙氨酸 

分 类 号：R318.08[医药卫生—生物医学工程]