大承气颗粒抗小鼠急性细菌性腹膜炎作用的研究  

Research on the therapeutic effect of Dachengqi granules(大承气颗粒) on acute bacterial peritonitis in mice

作　　者：杨凤蕊[1] 张金梁[1] 崔志清[1] 

机构地区：[1]天津医科大学药理教研室,天津300070

出　　处：《中药药理与临床》2009年第3期3-6,共4页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:观察大承气颗粒抗小鼠急性细菌性腹膜炎的作用。方法:采用给小鼠腹腔注射腹膜炎形成液的方法建立小鼠急性细菌性腹膜炎模型,比色法测定血清NO含量,放射免疫分析法测定血清TNF-α、IL-6及IL-1β的含量,并观察小肠及肝组织的形态学变化。结果:模型组小鼠血清NO、TNF-α、IL-6及IL-1β的含量明显增加,小肠及肝脏组织损伤加重;大承气颗粒给药组血清NO、TNF-α、IL-6及IL-1β的含量有不同程度的降低,小肠及肝组织的病理损伤减轻。结论:大承气颗粒能够通过减少炎症介质和细胞因子的生成,减轻对腹膜炎小鼠的损伤。To observe the therapeutic effect of Dachengqi granules on acute bacterial peritonitis in mice. Methods： Bacillus coli suspension was injected intraperitoneally as acute bacterial peritonitis model in mice. Level of NO in serum was analyzed by colorimetry, levels of TNF-α;IL-6 and IL-1β levels were decreased , pathologic lesions were lessened in Dachangqi granules. Conclusion： Dachengqi granules can inhibit production of inflammatory mediators and cytokines, and alleviate injury to mice with acute bacterial peritonitis

关 键 词：大承气颗粒 急性细菌性腹膜炎 NO、TNF-α、IL-6、IL-1β 

分 类 号：R285[医药卫生—中药学]