铜绿假单胞菌制剂在乳腺癌新辅助化疗中的应用  

Effect of neoadjuvant chemotherapy combined with pseudomonas aeruginosa preparation in patients with breast cancer

作　　者：徐峰[1] 唐中华[1] 李允山[1] 陈干农[1] 周恩相[1] 陈显玉[1] 易文君[1] 

机构地区：[1]中南大学湘雅二医院乳腺甲状腺外科,长沙410011

出　　处：《中南药学》2009年第8期626-629,共4页Central South Pharmacy

摘　　要：目的评价铜绿假单胞菌制剂在乳腺癌新辅助化疗中的使用价值。方法用非盲法随机对照实验,实验组乳腺癌患者30例,对照组30例,2组患者均行新辅助化疗,实验组加用铜绿假单胞菌制剂,治疗结束后评价疗效及毒副作用。结果实验组在新辅助化疗第2、3、4疗程后总有效率(RR)分别为76.7%、86.7%和93.3%,对照组分别为26.7%、53.3%和73.3%,2组疗效有显著性差异。实验组化疗前后Karnofsky评分无明显差别,而对照组化疗前后Karnofsky评分显著降低(P<0.05)。实验组和对照组最常见的毒性反应均为恶心呕吐、骨髓抑制以及脱发,但实验组较对照组发生率有明显的减少,而毒性反应程度亦有明显的减轻(P<0.05)。结论铜绿假单胞菌制剂在新辅助化疗中的联合使用能增加化疗的有效率,同时能增加患者的化疗承受能力,减轻化疗的毒副作用。Objective To evaluate the effect of neoadjuvant chemotherapy combined with pseudomonas aeruginosa preparation in patients with breast cancer. Methods Thirty patients were enrolled in an experimental group and treated with neoadjuvant chemotherapy combined with pseudomonas aeruginosa preparation. Another 30 patients were enrolled in a control group and treated with neoadjuvant chemotherapy only. The curative effect and toxic side effect were evaluated after neoadjuvant chemotherapy. Results The rimission rates （RR） after 2, 3 and 4 cycles of neoadjuvant chemotherapy in the experimental group （ 76.7%, 86.7% and 93.3%） were significantly higher than those in the control group （ 26.7%, 53.3% and 73.3%）. The most common toxic side effect in the both groups were nausea and vomitting, arrest of bone marrow and alopecia, but the incidence rate and degree of toxic side effects in control group were significently higher than those in the experimental group （P〈0. 05）. Conclusion Neoadjuvant chemotherapy combined with pseudomonas aeruginosa preparation can improve the curative effect of chemotherapy and relieve the toxic side effect.

关 键 词：乳腺癌 新辅助化疗 铜绿假单胞菌制剂 

分 类 号：R979.1[医药卫生—药品]