慢性阻塞性肺疾病患者外周血可溶性白介素-2受体和IL-8及T淋巴细胞亚群检测的意义  

Study the Significance Of Serum Interleukin-2 Receptor,Interleukin-8,T-lymphocyte Subgroup In The Patients With Chronic obstructive Pulmonary Disease

作　　者：袁开芬[1] 赵国厚[1] 杨建华[1] 沈雯[1] 范敏娟[1] 

机构地区：[1]昆明医学院第二附属医院干疗呼吸科,云南昆明650101

出　　处：《实用心脑肺血管病杂志》2009年第8期647-649,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)患者外周血可溶性白介素-2受体(SIL-2R)、IL-8、T淋巴细胞亚群(CD3、CD4、CD8)的相互关系及其意义。方法COPD患者急性发作期31例,缓解期31例,健康对照组30例,用ELISA法测定血清SIL-2R、IL-8,单克隆抗体免疫组化荧光染色法测定血清T淋巴细胞亚群CD3+、CD4+、CD8+,并进行统计学分析。结果COPD缓解期组与健康对照组比较,血SIL-2R、IL-8增高,CD3+降低,差异有统计学意义(P<0.01),CD4+、CD4+/CD8+、CD8+间差异无统计学意义(P>0.05)。COPD急性发作期组与对照组比较,血SIL-2R、IL-8、CD3+、CD4+、CD4+/CD8+、CD8+间差异均有统计学意义(P<0.05)。COPD急性发作期组与缓解期组比较,血SIL-2R、IL-8、CD3+、CD4+差异有统计学意义(P<0.05),CD4+/CD8+、CD8+差异无统计学意义(P>0.05)。结论COPD患者由于病程长、长期营养状况差,机体免疫功能低下。急性发作期更明显。因此,在对COPD患者急性期的治疗过程中,给予增强免疫治疗,加强营养支持,对于缩短患者病程,减少反复呼吸道感染有一定价值。Objective To study the significance of Serum Interleukin - 2 Receptor （ SIL - 2R）, Interleukin - 8 （ IL - 8）, T - lymphocyte subgroup in the patients with chronic obstructive Pulmonary Disease （COPD）. Methods In the patients with COPD during acute attack 31cases, remission group 31 cases, control group 30 cases, with ELISE method detect SIL -2R, IL - 8, immunofluorescence techniques detect CD3^＋, CD3^＋, CD8^＋ and analysis the significance of them. Results Patients with COPD during acute attack group compare with control group, SIL -2R, IL -8 are increase, the deference is very significant （P 〈0.01 ）, CD3^＋, CD4^＋, are decrease, CD8^＋ are increase, the deference is significant （P 〈 0. 05 ） CD4^＋/ CD8^＋ are decrease, but the deference is not significant （P 〉 0. 05）. Patients with COPD during remission group, compare with control group, SIL - 2R, IL - 8 are increase, CD3^＋ are decrease, the deference is very significant （ P 〈 0.01 ）, CD4^＋, CD4^＋/ CD8^＋ are decrease, CD8^＋ are increase, but the deference is not significant （P 〉 0.05）. acute attack group compare with remission group, SIL - 2R, IL-8 are increase significantly, the deference is very significant （P 〈0. 01 ）, CD3^＋, CD4^＋ are decrease, and the deference is significant （P 〈0.05）, CD4^＋/CD8^＋ are decrease, CD8^＋ are increase, but the deference is not significant （P 〉0.05）. Conclusion Because the patients with COPD have long time disease and have poor nutrition for long time, their cell - mediated immunity and humoral immunity are decrease, it is more apparent in the period of the acute disease. Therefore, in the treatment of the aged patients with COPD, it is worthwhile for shorten the disease time and decrease the repeat infections that give patients more nutrition support and immunoenhancement.

关 键 词：肺疾病 慢性阻塞性 可溶性白介素-2受体 白介素-8 T-淋巴细胞亚群 

分 类 号：R563[医药卫生—呼吸系统]