全身炎症反应综合征患儿凝血功能的改变及临床意义  

Changes of coagulation function and clinical significance in children with systemic inflammatory response syndrome

作　　者：周远茜[1] 彭健[1] 

机构地区：[1]广西壮族自治区玉林市第一人民医院儿内科,广西玉林537000

出　　处：《中国当代医药》2009年第16期58-59,61,共3页China Modern Medicine

摘　　要：目的:探讨全身炎症反应综合征患儿凝血功能的改变及临床意义。方法:选取符合SIRS诊断标准的患儿96例,根据SIRS符合项数分为S2、S3及S4组,根据预后分为存活组和死亡组。测定患儿凝血酶原时间(PT)、凝血酶时间(TT)、部分活化凝血活酶时间(APTT)、D-二聚体(DD)、血小板计数(PLT)、血小板平均体积(MPV),探讨其与凝血功能紊乱间的关系。结果:随着SIRS符合项数的增加,SIRS患儿的死亡率相应增高,PT、TT、APTT、DD也增高,具有明显的相关性,存活组与死亡组间PT、TT、APTT、DD及MPV比较,差异具有统计学意义(P<0.05)。结论:符合SIRS诊断标准项数越多,病情越严重、凝血功能紊乱显著、病死率高。Objective： To study the changes of coagulation function and its clinical significance in children with systemic inflammatory response syndrome（SIRS）.Methods：The patients were divided into the group S2,group S3 and group S4 ac cording to the 4 items of clinical criteria for diagnosis of SIRS.These patients were also divided into survival group and nonsurvival group according to the prognosis.Their prothrombin time （PT）,thrombin time （TT）,activated partial thromboplastic time （APTT） and the D-Dimer （DD） levels,plateiet counts （PLT） and mean plateiet vollumn （MPV） of 96 children diag nosed as SIRS were determined.Their coagulation function were compared.Results：The percentage of mortality rate in SIRS children increased with increasing items of criteria for diagnosis of SIRS,so did the PT,TT,APTT and DD levels.The PT,TT,APTT and DD levels remarkably correlated with the items.There was difference in the PT,TT,APTT, DD,MPV between the survival group and nonsurvival group （P〈0.05）.Conclusion：The more items of the diagnostic criteria for SIRS,the patients had the more severe and much remarkable the coagulation disturbance and much higher the mortality.

关 键 词：全身炎症反应综合征 凝血功能 临床意义 儿童 

分 类 号：R725.9[医药卫生—儿科]