5-氨基-3-巯基-1,2,4-三氮唑的合成工艺研究  

Study on Synthesis Technology of 5-Amino-3-mercapto-1 ,2 ,4-triazolo

作　　者：吴海涛[1] 陈天云[1] 管有志[1] 

机构地区：[1]合肥工业大学化学工程学院,安徽合肥230009

出　　处：《安徽化工》2009年第4期36-38,共3页Anhui Chemical Industry

摘　　要：以水合肼和硫氰酸铵为原料合成2,5-联二硫脲,在碱性条件下脱硫化氢环化制得5-氨基-3-巯基-1,2,4-三氮唑。研究了环化过程中原料配比、反应温度、反应时间对收率的影响,得到较佳的工艺条件:2,5-联二硫脲与NaOH的摩尔比为1∶5,反应时间为5h,反应温度125℃,在此工艺条件下,产品收率达到85.5%以上。In alkaline solution,the target compounds 5-amino-3-mercapto-1,2,4 triazolo were produced from a cyclization reaction of the 2,5-dithiobiurea which were synthesized by the starting material hydrazine hydrate and ammonium thiocyanate. The effect of the proportion of raw materials, the reaction temperature and the reaction time were investigated. The optimum reaction conditions were determined,i.e., n （2,5-dithiobiurea） ：n （sodium hydroxide） =1：5, reaction temperature 125℃ and reaction time 5h. The yield reached above 85.5% with the optimal process.

关 键 词：5-氨基-3-巯基-1 2 4-三氮唑 2 5-联二硫脲 合成工艺 

分 类 号：O626.26[理学—有机化学]