5-羟甲基噻唑的合成  

Synthesis of 5-hydroxymethylthiazole

作　　者：叶翠层[1] 肖红波[1] 殷作虎[1] 辛莎[1] 孙汉洲[1] 

机构地区：[1]中南林业科技大学应用化学研究所,湖南长沙410004

出　　处：《化学试剂》2009年第8期655-657,共3页Chemical Reagents

摘　　要：标题化合物是合成第二代抗AIDS药物利托那韦(Ritonavir)的中间体。以2-氯-5-氯甲基噻唑为原料,经过乙醇-氢氧化钠溶液水解,锌粉/醋酸还原脱氯,氢氧化钠水解合成5-羟甲基噻唑。在适宜的条件下,5-羟甲基噻唑总收率为66.2%。5-Hydroxymethylthiazole is an intermediate for synthesizing the second generation anti-AIDS drugs Ritonavir.5-Hydroxymethylthiazole was synthesized from 2-chloro-5-chloromethylthiazole through hydrolysis in the ethanol solution of NaOH,followed by reduction and dechlorination by zinc powder and acetic acid,and further hydrolysis in the caustic soda solution.Under optimal conditions the yield of 5-hydroxymethylthiazole was 66.2%.

关 键 词：5-羟甲基噻唑 2-氯-5-氯甲基噻唑 合成 锌粉/醋酸还原脱氯 

分 类 号：TQ252.5[化学工程—有机化工]