血浆同型半胱氨酸水平与冠心病关系的Meta分析  

Association between Plasma Homocysteine Level and the Prevalence of Coronary Heart Disease:A Meta-analysis

作　　者：苏健[1] 陆义萍[1] 凤尔翠[1] 高素琴[1] 刘艳青[1] 魏世敏[1] 刘起展[1] 

机构地区：[1]南京医科大学公共卫生学院,南京210029

出　　处：《中国循证医学杂志》2009年第8期862-865,共4页Chinese Journal of Evidence-based Medicine

基　　金：江苏省人事厅"六大人才高峰"A类项目资助(No:20041104);江苏省高等学校大学生实践创新训练计划项目资助(No:KY103J27001)

摘　　要：目的综合评价同型半胱氨酸(Hcy)水平与冠心病的关系,为预防和诊治冠心病提供依据。方法计算机检索中国期刊网全文数据库、中国生物医学文献数据库、万方数据库和维普数据库,并结合文献追溯的方法,收集国内公开发表的有关血浆Hcy水平与冠心病关系的病例对照研究,采用ReMan4.2软件进行Meta分析。结果共纳入10个研究,包括1732例研究对象。Meta分析结果显示,冠心病组Hcy水平明显高于正常对照组,其差异有统计学意义[WMD=4.88,95%CI(4.40,5.35),P<0.00001],失效安全数Nfs0.05为1339,提示Meta分析结果稳定可靠。结论高水平Hcy与冠心病发病关系密切。Objective To evaluate the association between coronary heart disease （CHD） and plasma homocysteine level, and to provide additional information for prevention and management of CHD. Methods We searched CBM, CNKI, WanFang, and VIP databases. Case-control studies about the association between CHD and plasma homocysteine level published in China were identified. Meta-analysis was performed using RevMan 4.2 software. Results The result of meta-analysis showed the plasma homocysteine level in the CHD group was higher than that of the control group （WMD=4.88, 95%CI 4.40 to 5.35, P〈0.000 01）, and the loss of safety coefficient was 1 339. Conclusion High plasma homocysteine level is associated with increasing morbidity of CHD.

关 键 词：血浆同型半胱氨酸 冠心病 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]