Meta分析中发表偏倚的Begg’s检验、Egger’s检验及Macaskill’s检验的SAS程序实现  

Applying the SAS Program to the Complete Begg’s Test,the Egger’sTest,and the Macaskill’s Test for Publication Bias of Meta-analysis

作　　者：郑辉烈[1,2] 王忠旭[3] 王增珍[1] 

机构地区：[1]华中科技大学同济医学院公共卫生学院流行病与卫生统计系,武汉430030 [2]南昌大学医学院公共卫生学院流行病与卫生统计系,南昌330006 [3]中国疾病预防控制中心,北京100050

出　　处：《中国循证医学杂志》2009年第8期910-916,共7页Chinese Journal of Evidence-based Medicine

基　　金：国家科技部973课题(2002CB512910)

摘　　要：Meta分析的结论易受各种偏倚的影响,"发表偏倚"是其中重要的偏倚之一。所以,评价所纳入的研究是否存在发表偏倚是Meta分析的一项重要的前期准备工作。Begg’s检验、Egger’s检验和Macaskill’s检验是常见的用于定量评价Meta分析"发表偏倚"的方法,为了便于这些检验方法的应用,本文编写了基于SAS系统的这三个检验的程序,经实例数据分析,其运行结果与Stata软件完全相同。为研究人员提供了同时实现这三个检验的有效途径。The conclusions of meta-analyses are susceptible to various of biases, and publication bias is one of such main bias. Therefore, Checking for evidence of publication bias should be undertaken routinely at the preliminary stage of a meta-analysis. Begg＇s test, Egger＇s test, and Macaskill＇s test are usually used to objectively identify publication bias in meta-analyses. In order to conveniently use these methods, the SAS program of these three tests was designed in this paper. In order test practical data, the fact that the output of this program of SAS software was consisted with the output of STATA software was validated. So, this program is an alternative way to do such hypothesis tests to identify the publication bias in meta-analyses.

关 键 词：META分析 发表偏倚 Begg’S检验 Egger’S检验 Macaskill’S检验 

分 类 号：R195[医药卫生—卫生统计学]