多聚磷酸盐在原核和真核生物中的研究进展  

Progress in Functional Polyphosphate in Prokaryotic and Eukaryotic Living Organisms

作　　者：魏峥[1] 聂琰晖[1] 刘乐庭 卢洁[1] 于常海[1] 

机构地区：[1]北京大学神经科学研究所/基础医学院神经生物学系教育部神经科学重点实验室卫生部神经科学重点实验室,100191

出　　处：《生理科学进展》2009年第3期197-202,共6页Progress in Physiological Sciences

基　　金：国家高技术研究发展计划(863计划)(2006AA02Z452);国家自然科学基金(30270426,30470543,30670644);北京市自然科学基金(7032026,7051004,7091004)资助课题

摘　　要：多聚磷酸盐(polyphosphate,poly P)广泛存在于自然界无机环境和生命有机体。细菌学研究显示,poly P可增强细胞抵抗外界恶劣环境的能力,促进严瑾反应(strigent response)和孢子形成,促进生物被膜的形成,提高捕食能力,增强细菌毒力等。对真核生物的研究发现,poly P可以促进正常成骨细胞和成纤维细胞分化成熟,参与胞内钙的贮存与释放,刺激一些肿瘤细胞增殖等。本文从现有的信息入手,推测poly P在神经系统中的功能。Polyphosphate （poly P） has been widely identified in both inorganic environment and living organisms. Research shows that poly P in bacteria enhances their resistance to severe environment, triggers their protective responses, increases biofilm formation and involves in predation and bacterial viru- lence. In eukaryotes, poly P has been found to enhance the proliferation of fibroblast and many tumor cell lines, induce the calcification of osteoblast and be involved in calcium ion release. Based on the existing information, we attempt to discuss the possible functions of poly P in the nervous system.

关 键 词：多聚磷酸盐 中枢神经系统 多聚磷酸盐激酶 外切聚磷酸酶 

分 类 号：Q42[生物学—神经生物学]