磷脂酰乙醇胺结合蛋白的基础和临床研究  

Phosphatidylethanolamine-binding Protein (PEBP) in Basic and Clinical Study

作　　者：李芳芳[1] 宋士军[2] 张若楠[1] 

机构地区：[1]河北医科大学生物化学与分子生物学教研室,石家庄050017 [2]河北医科大学生理学教研室,石家庄050017

出　　处：《生理科学进展》2009年第3期214-218,共5页Progress in Physiological Sciences

摘　　要：磷脂酰乙醇胺结合蛋白(phosphatidylethanolamine-binding protein,PEBP)是一类高度保守的多功能蛋白质,广泛存在于不同物种中。在同一物种的多种组织和不同类型细胞中均有表达。PEBP在多条信号转导通路中具有重要的调控作用。PEBP通过与Raf-1相互作用抑制MAPK信号通路的活性,因此也被称为Raf-1激酶抑制蛋白(RKIP);同时,PEBP还参与了PKC、G蛋白偶联受体和NF-κB信号通路的调控。在临床医学研究中发现,PEBP作为海马胆碱神经刺激肽(HCNP)的前体蛋白在阿尔采末病(AD)的形成过程中发挥重要作用。由于PEBP可以抑制肿瘤转移和促进肿瘤细胞凋亡,因此也被认为是一种肿瘤转移的抑制基因。新近研究表明,PEBP参与细胞周期的纺锤体检查点的调控,PEBP的缺失可导致染色体异常。在直肠结肠癌,PEBP基因启动子区的高甲基化可导致其不表达,这可能是癌症转移的分子基础。Phosphatidylethanolamine-binding protein （PEBP） is a highly conserved group of multitunctional proteins found in a variety of different species. In the same species, it is expressed in numerous tissues and cell types. PEBP plays a pivotal modulatory role in several signal transduction pathways. PEBP inhibits the MAPK pathway through interacting with Raf-1, so it＇s also known as Raf-1 kinase inhibitor protein （RKIP）. PEBP is involved in the regulation of PKC, G-protein-coupled receptor and NF-KB signaling pathway as well. In clinical researches, it was found that as the precursor of hippocampal cholinergic neurostimulating peptide （HCNP）, PEBP has an important effect on the development of Alzheimer＇s disease. Recent evidence imply that PEBP function as a metastasis suppressor gene because it can suppress metastasis and promote apoptosis in tumor cells. In coloreetal cancer, high methylation of the promoter region of PEBP gene results in the non-expression of PEBP, that maybe the molecular basis of tumor metastasis. The latest studies demonstrate that PEBP regulates the spindle checkpoint in cell cycle and loss of PEBP can leads to chromosomal abnormalities.

关 键 词：磷脂酰乙醇胺结合蛋白 信号转导 阿尔采末病 肿瘤转移抑制基因 

分 类 号：Q71[生物学—分子生物学]