姜黄抗运动性疲劳效果与作用机制研究  

Anti-Sports-Fatigue Effects and Mechanism of Curcuma Longa

作　　者：王建治[1] 周福波[2] 杨静[3] 米彦军[4] 

机构地区：[1]牡丹江医学院体育教学部,黑龙江157011 [2]牡丹江医学院药学系,黑龙江157011 [3]哈尔滨医科大学临床3系,150081 [4]牡丹江医学院动物机能实验室,黑龙江157011

出　　处：《医药导报》2009年第8期980-982,共3页Herald of Medicine

基　　金：黑龙江省教育厅科学技术项目(基金编号:11531406)

摘　　要：目的研究中药姜黄抗运动性疲劳效果及其作用机制。方法灌胃给予不同剂量姜黄30d后,进行小鼠爬杆实验、耐缺氧实验和大鼠骨骼肌收缩力学实验,并测定大鼠比目鱼肌超氧化物歧化酶(SOD)、丙二醛(MDA)和Ca2+-Mg2+-ATP酶活性。结果姜黄能明显延长小鼠爬杆时间、增强耐缺氧能力,可使大鼠骨骼肌收缩力增强,SOD和Ca2+-Mg2+-ATP酶活性增强、MDA值降低。结论姜黄在增加机体对运动负荷的适应能力、抵抗疲劳产生和加速疲劳消除方面具有明显的作用。Objective To investigate the anti-sports-fatigue effect of Chinese medicine curcuma longa and its mechamism. Methods Continuously pole climbing and anti-anoxia experiments were carried out on mice which were given with curcuma longa intragastfically at different doses for 30 days. The skeletal muscle contraction of rats and content of superoxide dismutase（ SOD ）, malonaldehyde （MDA） and Ca^2＋ -Mg^2＋ -ATPase activity were detected. Results It was showed that curcuma longa obviously prolonged the time of climbing, raised anti-anoxia capability of mice, enforced the contraction of skeletal muscle and increased activities of Ca^2＋ -Mg^2＋ -ATPase and SOD, lowered the content of MDA. Conclusion Curcuma Zonga may have significant effect on the capability of adaptation to heavy exercise and prevention or elimination fatigue after exercise.

关 键 词：姜黄 抗疲劳 超氧化物歧化酶 丙二醛 Ca2+-Mg2+-ATP酶 

分 类 号：R286[医药卫生—中药学] R965[医药卫生—中医学]