凝血酶和奥美拉唑治疗新生儿窒息后急性胃黏膜出血的疗效观察  

Observation of the curative effect of thrombin and Omeprazole to treat neonates with acute stomach mucous membrane bleeding after suffocation

作　　者：郭瑜 

机构地区：[1]广东省高州市妇幼保健院,525200

出　　处：《中国医学创新》2009年第23期27-28,共2页Medical Innovation of China

摘　　要：目的探讨凝血酶和奥美拉唑(洛赛克)治疗新生儿窒息后胃黏膜出血的疗效。方法将52例新生儿窒息后胃黏膜出血患儿随机分为对照组22例和观察组30例,观察组在常规洗胃后将凝血酶500 U溶于3～5 ml0.9%氯化钠注射液中,经胃管注入胃内,每8 h 1次;同时用奥美拉唑0.6～0.8 mg/kg,每日1次静脉滴注,至胃内出血停止。结果观察组总有效率96.7%,对照组总有效率68.2%(P<0.05)。结论凝血酶和奥美拉唑治疗新生儿窒息后急性胃黏膜出血疗效显著,能缓解症状,缩短病程,提高治愈率,安全、有效、简便,值得临床推广应用。Objective To investigate the curative effect of Thrombin and Omeprazole to treat neonates with stomach mucous membrane bleeding after suffocation. Methods 52 patients with stomach mucous membrane bleeding after suffocation were divided at random into a control group of 22 patients and a treatment group of 30 patients with 500 U thrombin dissolved into 3 - 5 ml physiological saline injected into the stomach after washing the stomach in routine, once every 8 hours and Omeprazole 0. 6 -0. 8 mg/（ kg· d） injected until the haemorrhage stopped. Results The total curative effect of the treatment group was 96. 7%, while that of the control group was 68.2%, which had significant differences （P 〈0. 05）. Conclusion Thrombin and Omeprazole has a good curative effect in the treatment of neonates with acute bleeding in mucous membrane of stomach after suffocating, alleviate the symptom, shorten the course of diseases, and is safe and simple.

关 键 词：凝血酶 奥美拉唑 新生儿 窒息 胃黏膜出血 

分 类 号：R722.1[医药卫生—儿科]