胶原性关节炎大鼠血清中IL-17水平的分析  

measurement of IL-17 from sera in collagen-induced arthritis

作　　者：李霞[1] 赵彩红[1] 裘红梅[1] 

机构地区：[1]大连大学医学院免疫教研室,辽宁大连116622

出　　处：《中国现代医学杂志》2009年第14期2135-2137,共3页China Journal of Modern Medicine

基　　金：中华医学会风湿病分会发展与研究基金(No:2008114)

摘　　要：目的检测胶原性关节炎(collagen-induced arthritis,CIA)大鼠血清IL-17的水平,并分析其与抗II型胶原(CollagenⅡ,CII)抗体以及关节炎症指数的关系。方法建立CIA模型,ELISA法检测IL-17及抗CII抗体的水平;并观察CIA大鼠炎症指数。结果CIA大鼠血清IL-17和抗CII抗体水平均高于对照组,且CIA组IL-17与关节炎炎症指数和血清抗CII抗体水平呈正相关关系。结论CIA大鼠血清IL-17水平升高,且与病情活动有关。[Objective] To detect the level of IL-17 from sera in collagen-induced arthritis （CIA） and analyze the rolatronship between IL-17 and anti-conagen Ⅱ（CⅡ） antibody as well as atrhritisindex. [Methods] The models of CIA were established. The levels of IL-17 and anti-CII antibody were examined by ELISA. The arthritis index in CIA rats was observed. [Results] The levels of IL-17 and anti-CⅡ antibody in CIA group were significantly higher than that in control group （P 〈0.05）. There was positive correlation between IL-17 and arthritis index as well as anti CⅡ antibody. [Conclusion] Higher level of IL-17 in CIA was assocaited with disease activity.

关 键 词：胶原性关节炎 IL-17 抗CII抗体 炎症指数 

分 类 号：R684.3[医药卫生—骨科学]