体外受精胚胎移植过程中受精障碍原因分析  

Clinical reasons of fertilization failure undergoing in vitro fertilization and embryo transplantation

作　　者：任建枝[1] 李萍[1] 沙爱国[1] 蒋晓明[1] 周友泉[1] 韩冬梅[1] 

机构地区：[1]解放军第一七四医院生殖医学中心,福建厦门361002

出　　处：《临床医学》2009年第8期1-3,共3页Clinical Medicine

摘　　要：目的探讨常规体外受精(IVF-ET)治疗过程中卵子完全受精失败或受精率低下的临床原因。方法回顾性分析2007年2月至2008年12月常规IVF-ET治疗660周期。根据受精率情况分成受精障碍组78例和受精正常组582例两组,对两组的女方年龄、促排卵方案、获卵数、卵成熟比率、不孕原因进行分析。结果IVF-ET受精率低下占总数的11.82%,其中受精完全失败者占受精异常的47.37%。两组间患者的年龄、不孕年限、促排卵方案、获卵数、卵成熟比率差异无统计学意义。受精异常组原发不孕症比率明显增高,伴有男性因素及不明原因患者受精异常率高。结论原发不孕、不明原因及伴有轻中度男方少弱畸精症的患者在行IVF-ET助孕时可能存在受精失败。Objective To explore the clinical reasons of total fertilization failure and low fertilization rate in vitro fertilization and embryo transplantation（ IVF - ET）. Methods Total 660 cycles undergoing IVF - ET from February 2007 to December 2008 were included in this study. They were divided into fertilization failure group consisted of 78 cases and fertilization normal group consisted of 582 cases according to fertilization rate. The femal age, duration of infertility, ovarian stimulation protocol, oocyte retrieval, rate of mature oocytes and cause of infertility between the two groups were compared. Results The rate of low fertilization was 11.82% and total fertilization failure was 47.37% in all fertilization failure group after IVF - ET. There was no difference between the femal age, duration of infertility, ovarian stimulation protocol, oocyte retrieval , rate of mature oocytes. The fertilization failure was found higher in primary infertility patients. The fertilization failure was higher in primary infertility, unexplained infertility patients and other cause infertility accompany by mild - moderate male factor. Conclusion Fertilization failure may be occurred in primary infertility, the unexplained infertility patients and other cause accompany by male factor.

关 键 词：体外受精 受精障碍 

分 类 号：R714.8[医药卫生—妇产科学]