微波辐射相转移催化合成6-甲基脲嘧啶  

Synthesis of 6-Methyluracil Using PEG-500 as Catalyst under Microwave Irradiation

作　　者：凌绍明[1] 赵承强[2] 

机构地区：[1]百色学院化学与生命科学系,广西百色533000 [2]河池学院化学与生命科学系,广西宜州546300

出　　处：《化学世界》2009年第8期485-487,475,共4页Chemical World

摘　　要：以乙酰乙酸乙酯和尿素为原料,聚乙二醇-500(PEG-500)为相转移催化剂,在微波辐射下合成了6-甲基脲嘧啶。探讨了催化剂用量、原料配比、微波功率、微波辐射时间、相转移催化剂种类及相转移催化剂用量对6-甲基脲嘧啶收率的影响。较适宜的反应条件为:n(尿素)∶n(乙酰乙酸乙酯0.05mol)为1.2∶1.0,PEG-500用量0.5g,对甲苯磺酸用量0.5g,微波功率324W,反应时间4min,收率88.3%。6-Methyluracil was synthesized from ethyl acetoacetate and urea using PEG-500 as phase transfer catalysts （PTC） under microwave irradiation. The effects of different factors, such as the kinds of phase transfer catalysts （PTC）,the quantity of PTC,the mole ratio of urea to ethyl acetoacetate, the microwave power,the irradiation time and the quantity of p-toluene sulfonic acid on the yield of product were investigated. The appropriate reaction conditions were as follows：ethyl acetoacetate was 0.05 mol,n（urea） ： n（ethyl acetoacetate）= 1.2 ： 1.0, the amount of PEG-500 was 0.6 g,the amount of p-toluene sulfonic acid was 0.6 g, the power of microwave was 324 W and the irradiation time was 4 min. The yield of 6- methyluracil was 88.3%.

关 键 词：微波辐射 6-甲基脲嘧啶 相转移催化 乙酰乙酸乙酯 尿素 

分 类 号：TQ254.1[化学工程—有机化工]