Fluctuation Resonance of Feed Forward Loops in Gene Regulatory Networks  

基因网络前馈环路中的涨落共振

作　　者：董翊[1] 侯中怀[1] 辛厚文[1] 

机构地区：[1]中国科学技术大学合肥微尺度科学国家实验室,化学物理系,合肥230026

出　　处：《Chinese Journal of Chemical Physics》2009年第4期359-365,447,共8页化学物理学报（英文）

基　　金：ACKNOWLEDGMENT This work was supported by the National Natural Science Foundation of China （No.20673106）.

摘　　要：The feed forward loop （FFL）, wherein a gene X can regulate target gene Z alone or cooperatively with gene Y, is one of the most important motifs in gene regulatory networks. Gene expression often involves a small number of reactant molecules and thus internal molecular fluctuation is considerable. Here we studied how an FFL responds to small external signal inputs at gene X, with particular attention paid to the fluctuation resonance （FR） phenomenon of gene Z. We found that for all coherent FFLs, where the sign of the direct regulation path from X to Z is the same as the overall sign of the indirect path via Y, the FR shows a regular single peak, while for incoherent FFLs, the FR exhibits distinct bimodal shapes. The results indicate that one could use small external signals to help identify the regulatory structure of an unknown FFL in complex gene networks.

关 键 词：Gene regulatory network Fluctuation resonance Feed-forward-loop 

分 类 号：O321[理学—一般力学与力学基础] TP11[理学—力学]