参麦注射液对血液透析患者营养不良——炎症综合征的影响  

Effect of Shenmai Injection on Patients Suffering from Malnutrition-Inflammation Complex Syndrome during the Maintenance Hemodialysis

作　　者：张雯[1] 陶筱娟[1] 程军[1] 汪卫[1] 王璞[1] 程擎天[1] 羊淑敏[1] 

机构地区：[1]浙江中医药大学附属中西医结合医院肾内科,杭州310003

出　　处：《中国中西医结合杂志》2009年第8期703-706,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：浙江省中医药管理局青年基金项目(No.2006Y051)

摘　　要：目的研究参麦注射液对维持性血液透析(maintenance hemodialysis,MHD)患者营养不良—炎症综合征(Malnutrition-inflammation Complexsyndrom,MICS)的影响。方法MHD患者40例,随机分为参麦组(20例)和对照组(20例),治疗3个月,观察治疗前后血白蛋白(Alb)、血清超敏C反应蛋白(high sensitive C-reactive protein,hs-CRP)、白介素-6(interleukin 6,IL-6)、白介素-1β(interleukin 1βeta,IL-1β)水平及测量人体学指标(包括TSF、AMC、SSF及MAMC),同时用改良主观综合性营养评估表(改良SGAN法)进行营养评估,采用定量的评分系统(malnutrition score,MS)得出MS值。结果参麦组治疗后与治疗前比较,MS值、hs-CRP、IL-6、IL-1β均明显降低(P<0.01,P<0.05),Alb、体重(BW)、SSF水平明显升高(P<0.05,P<0.01);治疗后,与对照组比较,MS值、hs-CRP、IL-6水平均明显降低(P<0.01,P<0.05),SSF、Alb水平明显升高(P<0.01,P<0.05);参麦组及对照组分别与健康志愿者比较,IL-6、IL-1β水平均明显升高(P<0.05);Alb与MS值具有显著相关(P<0.01),IL-6与Alb、MS值明显相关(P<0.05)。结论参麦注射液能降低MHD患者血hs-CRP、IL-6、IL-1β水平,改善营养指标,提示参麦注射液可以改善MHD患者MICS。Objective To investigate the effect of Shenmai Injection （SMI） on patients undergoing maintenance hemodialysis （MHD） suffered from malnutrition-inflammation complex syndrome （MICS）. Methods Forty patients undergoing MHD were randomly allocated into two groups, the SMI group and the control group, 20 in each group. They were treated for three months. Blood levels of albumin （AIb）, high-sensitivityC-reactive protein （ hs-CRP）, interleukin 6 （IL-6） and interleukin 1β （IL-1β） as well as somatologic parameters were measured before and after treatment. Meantime, the modified subjective global analysis of nutrition （SGAN） was used to assess patients＇ nutritional status, and the quantitative scoring system was adopted to get the malnutrition score （MS）. Results In the SMI group after treatment, levels of MS, hs-CRP, IL-6 and IL-1β were lowered, levels of AIb, body weight, and SSF were increased significantly （ P 〈 0.05 or P 〈 0.01 ） ; as compared with those in the control group, MS, hs-CRP and IL-6 were lower, while SSF and AIb were higher （P〈0. 05 or P〈 0.01）. Levels of IL-6 and IL-1β, either in the SMI group or in the control group, were all higher than normal range （ P 〈 0.05）. Correlation analysis showed significant correlation presented between MS value with levels of AIb （P〈0.01） and IL-6 （P〈0.05）, also between IL-6 and AIb （P〈0.05）. Conclusion SMI can reduce the blood levels of hs-CRP, IL-6 and IL-1β in patients undergoing MHD, improve their nutritional indices, suggesting that it could alleviate the MICS in these patients.

关 键 词：参麦注射液 血液透析 营养不良-炎症综合征 

分 类 号：R259[医药卫生—中西医结合]