加味玉屏风合剂防治小儿反复呼吸道感染100例临床观察  

Clinical Observation of Effect of Jiawei Yupingfeng Mixture for Prevention and Treatment of 100 Children with Repeated Respiratory Tract Infection

作　　者：王绍洁[1] 矫承媛[1] 孙小迪[1] 

机构地区：[1]辽宁省大连市儿童医院中医科,辽宁116012

出　　处：《中国中西医结合杂志》2009年第8期742-745,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察中药加味玉屏风合剂对反复呼吸道感染(RRTI)的临床疗效、T细胞亚群(CD3+、CD4+、CD8+及CD4+/CD8+)、免疫球蛋白(IgG、IgA、IgM)及红细胞免疫指标(C3b、ICR、RFER及RFIR)的影响。方法将200例患儿分为观察组(加味玉屏风合剂治疗)和对照组(转移因子治疗),每组各100例,观察临床疗效,并从两组中各随机抽取31例患者测定治疗前后T细胞亚群、免疫球蛋白及红细胞免疫指标。结果观察组用药后发病次数减少,病程缩短,病情减轻不明显;与对照组用药后比较,发病次数减少、病程的缩短差异均有统计学意义(P<0.01)。治疗后两组IgG、IgA均有改善,与对照组比较,观察组IgG、IgA值上升更明显,差异有统计学意义(P<0.05,P<0.01)。治疗后观察组CD3+、CD4+、CD8+、CD4+/CD8+显著改善,与本组治疗前比较,差异有统计学意义(P<0.01);对照组治疗后CD3+、CD4+升高明显,差异有统计学意义(P<0.05,P<0.01);CD8+、CD4+/CD8+改善不明显,差异无统计学意义(P>0.05);与对照组治疗后比较,观察组CD3+、CD4+、CD8+明显改善,差异有统计学意义(P<0.01)。观察组治疗后红细胞免疫各项指标明显改善,与本组治疗前比较,差异有统计学意义(P<0.01);对照组治疗后C3b、RFER、RFIR差异有统计学意义(P<0.05,P<0.01),ICR改善不明显;与对照组治疗后比较,观察组各项指标明显改善,差异均有统计学意义(P<0.01)。结论加味玉屏风合剂能通过调节白细胞免疫、体液免疫及红细胞免疫而起到防治儿童反复呼吸道感染的作用。Objective To investigate the effect of Jiawei Yupingfeng Mixture （YPF） on repeated respiratory tract infection （RRTI） and its impacts on T-cell subsets, immunoglobulin and erythrocyte immune. Methods Two hundred children with RRTI were assigned equally to two groups, the test group treated with YPF and the control group treated by transfer factor. The clinical efficacy, and the changes of T-cell subsets, immunoglobulin and erythrocyte immune before and after treatment were observed in 31 patients randomly selected from each group. Results After treatment, the frequency of attacking was reduced and the course of attacking was shortened significantly in the test group as compared with before treatment and also with the control group （ P 〈 0. 01 ） ; IgG and IgA levels were improved in both groups, but the improvement was more significant in the test group （P〈0. 01, P 〈0.05）; T-cell subsets indices, including CO3^＋, CO4^＋, CO8^＋ and CO4^＋/CD8^＋ ratio, all improved in the test group significantly （ P 〈0.01 ）, while in the control group, significant improvement only showed in rising of CD3＋ and CD4 （ P 〈 0. 05, P 〈 0. 01 ）, comparison between groups showed significant difference in terms of CD3^＋ , CD4^＋ and CD8^＋ ; in the control group, levels of C3b, RFER and RFIR were changed significantly （P〈0. 05, P〈0. 01 ）, but the improvement of ICR was insignificant, while in the test group, the above indices were significant improved as compared with after treatment of the control group （ P 〈 0. 01 ）. Conclusion YPF plays a preventive and therapeatic role in children with RRTI by way of regulating the cellular and humoral immune.

关 键 词：加味玉屏风合剂 小儿反复呼吸道感染 免疫球蛋白 T细胞亚群 红细胞免疫 

分 类 号：R272[医药卫生—中医儿科学]