含哌嗪类抗微生物药物研究进展  

Recent advance in the research of piperazine-containing compounds as antimicrobial agents

作　　者：蔡佳利[1] 卢一卉[1] 甘淋玲[2] 张奕奕[1] 周成合[1,2] 

机构地区：[1]西南大学化学化工学院,重庆400715 [2]西南大学药学院,重庆400715

出　　处：《中国抗生素杂志》2009年第8期454-462,484,共10页Chinese Journal of Antibiotics

基　　金：重庆市自然科学基金(CSTC2007BB5369);西南大学人才引进基金(SWUB2006018);西南大学高新技术培育基金(XSGX0602)

摘　　要：含哌嗪类化合物在抗微生物药物方面的研究开发较为活跃。本文结合国内外文献简述了在抗疟、抗菌、抗结核、抗真菌、抗病毒等方面已经上市及正在进行临床试验的含哌嗪类抗微生物药物,着重强调了含哌嗪的抗微生物药物及其构效关系的研发近况。随着研究的深入,有望成功地开发出更多具有克服多药耐药性的高效低毒哌嗪类抗微生物药物。The researches of piperazine-containing compounds are increasingly active. In this review we presented the recent advances of piperazine-containing compounds as antimalarial, antibacterial, antitubercular, antifungal, antiviral agents and so on, and emphasized their structures-activity relationships. Further researches and developments will result in more and more effective and low-toxic antimicrobial agents to conquer multidrug resistance.

关 键 词：哌嗪 抗疟 抗结核 抗菌 抗真菌 抗病毒 

分 类 号：R978.1[医药卫生—药品]