高尿酸血症与甲状腺功能异常关系的相关性研究  

Relationship between the prevalence of hyperuricemia and thyroid dysfunction

作　　者：毛玉山[1] 刘志民[1] 王侠[2] 陈长喜 黄童[4] 洪中立[4] 

机构地区：[1]第二军医大学附属上海长征医院内分泌科,200003 [2]第二军医大学图书馆 [3]宁波市镇海炼化医院内科 [4]宁波大学医学院附属医院心内科

出　　处：《中华风湿病学杂志》2009年第8期528-530,共3页Chinese Journal of Rheumatology

摘　　要：目的探讨高尿酸血症与甲状腺功能异常的关系。方法调查10405名21～89岁某石化企业员工人群，询问甲状腺疾病的手术、药物治疗史，检测血促甲状腺素（TSH）、游离甲状腺素（FT4）、游离三碘甲状腺原氨酸（FT3）和血尿酸（SUA）。结果①该人群中高尿酸血症总患病率17．9％，男性22．6％，女性7．1％。②甲状腺疾病总体知晓率1．7％，男性0．9％，女性3．5％。③10232名否认甲状腺疾病史者中，甲状腺功能异常总患病率4．2％，男性2．9％，其中TSH降低者0．4％，TSH升高者2．5％；女性7．2％，其中TSH降低者0．9％，TSH升高者6．3％。④与TSH正常组相比，不论性别，TSH升高组的血尿酸均显著升高（P〈0．05），TSH降低组的血尿酸无显著变化。⑤TSH升高是高尿酸血症的独立影响因素（OR值男性为1．61、女性为1．72，P〈0．01）。结论高尿酸血症患病率与TSH升高显著相关，临床或亚临床甲状腺功能减退症可能是高尿酸血症的危险因素。Objective To study the relationship between the prevalence of hyperuricemia and thyroid dysfunction. Methods 10 405 active and retired workers aged 21 to 89 years in a Petrochemical Corporation in Ningbo area of Zhejiang Province were included. Serum thyroid-stimulation hormone （TSH）, free thyroxine （FT4）, free triiodothyronine （FT3） and serum uric acid （SUA） were measured. Results ① The prevalence of hyperuricemia was 17.9% of the population, 22,6% in male and 7,1% in female. ② The prevalence of past thyroid diseases was 1.7%, 0.9% in male and 3.5% in female. ③In 10232 individuals without history of thyroid diseases, the prevalence of thyroid dysfunction was 4.2%, 2.9% in male and 7.2% in female. The percentage of subjects with low TSH concentration was 0.4% in male and 0.9% in female,the percentage of subjects with elevated TSH concentration was 2.5% in male and 6.3% in female. ④ Compared with normal TSH subjects,the serum uric acid was significantly increased in subjects with high TSH （P〈0.05） and not changed in subjects with low TSH in both genders. ⑤Logistic regression analysis revealed that high TSH was an independent factor associated with hyperuricemia （OR=1.61 for male and 1.72 for female, P value was less than 0.01 for both）. Conclusion The prevalence of hyperuricemia is significantly associated with increased TSH concentration. Overt or subclinical hypothyroidism may be risk factors for hyperuricemia.

关 键 词：高尿酸血症 促甲状腺素 甲状腺疾病 流行病学 

分 类 号：R686[医药卫生—骨科学]