乳腺原发淋巴瘤的临床病理分析  

Clinical and Patholgical Analysis on Primary Lymphoma of Breast

作　　者：庄競[1] 夏庆欣[2] 高阳[1] 

机构地区：[1]河南省肿瘤医院普外科,郑州市450008 [2]河南省肿瘤医院病理科,郑州市450008

出　　处：《医药论坛杂志》2009年第13期9-11,共3页Journal of Medical Forum

摘　　要：目的探讨乳腺原发淋巴瘤的临床特点,病理形态及鉴别诊断。方法报道8例乳腺非何杰金氏淋巴瘤,结合文献对其进行综合讨论。结果8例组织学表现为弥漫增生的大B细胞围绕残存的小叶及导管,间质有不同程度的硬化,间质弥漫浸润T淋巴细胞,组织细胞,免疫组织化学染色:肿瘤细胞CD3-,CD20+,CD45RO-,CD79a+,CD68-CK-,乳腺肿块的大小、临床分期和治疗模式是预后的主要因素。结论乳腺原发淋巴瘤极为少见,以B细胞性多见,常为中—高度恶性,应注意与淋巴细胞性乳腺炎和浸润性小叶癌鉴别,本病在局部切除的基础上辅助全身化疗,疗效好。Objective To study the histopathologic features,clinical character and its differential diagnosis of the primary lymphoma of breast.Methods Total 8 cases of the primary lymphoma of breast were studied and literature reviewed.Results The cases histopathologic feature： the large B cell diffused hyperplasia and rounded the lobular catheter of residual,mesenchyma sclerosis and T cell,histocyto cell were diffused infilteration.Immunohistochemistry： the large cell CD3-,CD20＋,CD45RO-,CD79a＋,CD68-,CK-,,the size of tumor at diagnosis ,clinical stage and treatment pattern were significant prognostic factors in predicting the survial time. Conclusion The primary lymphoma of breast is a rare disease. The B cell lymphoma is usual type. They usually are middle - high - grade malignant noplasms,it can be differentiated from lymphocyte breast disease and invasive lobular carcinoma, the effect of the treatment was good for the systemic chemotherapy on the base of local treatment.

关 键 词：乳腺原发淋巴瘤 组织病理学 诊断 治疗 

分 类 号：R446.8[医药卫生—诊断学]