消炎痛、红霉素预防胆囊结石形成的实验研究  

An Experiment Study of Indomethacin and Erythromycin on Gallstone Prevention

作　　者：张继红[1,2] 杨可桢[1,2] 韩本立 

机构地区：[1]广州军区广州总医院肝胆外科 [2]第三军医大学西南医院肝胆外科

出　　处：《中国普通外科杂志》1998年第3期129-132,共4页China Journal of General Surgery

摘　　要：为进一步探讨胆汁成份异常、胆囊动力学变化和胆囊结石形成之间的内在联系，对家兔胆囊结石动物模型进行了胆囊动力学研究。结果显示：除胆汁成份异常外，胆囊动力学变化参与了胆囊结石形成。消炎痛能减少胆汁粘蛋白含量抑制胆固醇成核过程而防止胆囊结石形成；而红霉素能通过促进胆囊收缩同时减少胆汁粘蛋白含量和促进胆囊排空，从而更有效地防止胆囊结石形成。提示：改善致石胆汁引起的胆囊动力学变化较改变胆汁成分更有利于防止胆囊结石形成。In order to investigate the relation of abnormal bile components, the alteration of gallbladder dynamics and gallstone formation, we observed gallbladder dynamics in rabbit gallstone model. The results showed that: besides the abnormal bile components, the gallbladder dynamics participated in gallstone formation. Indomethacin could prevent gallstone formation by reducing mucosa protein in bile; Erythromycin could not only promote gallbladder emptying but also reduce mucosa protein in bile by promoting gallbladder contraction, so it could prevent gallstone formation effectively. The results suggest that: altering gallbladder dynamics in preventing gallstone formation is more effective than changing bile components.

关 键 词：胆囊 动力学 消炎痛 红霉素 胆结石 预防 

分 类 号：R657.42[医药卫生—外科学]