心钠素治疗妊高征的临床研究  

Clinical study on the therapy of pregnancy-induced hypertension(PIH)with atrial natriuretic polypeptide(ANP).

作　　者：杨梦庚[1] 邱学华[1] 王金声[1] 尹国武[1] 李东红[1] 张利朝[1] 梁国栋[1] 施溥涛[2] 

机构地区：[1]第四军医大学唐都医院 [2]上海生化研究所

出　　处：《中国实用妇科与产科杂志》1998年第4期218-220,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的：探讨心钠素治疗妊高征的临床效果及机理。方法：心钠素治疗妊高征病人６０例，硫酸镁治疗妊高征病人３０例。观察治疗前后血压、尿蛋白、血心钠素、超氧化物歧化酶、肾素、血管紧张素、醛固酮的变化。结果：病人经心钠素治疗后，血压明显下降，尿蛋白转阴，水肿消退，血中超氧化物歧化酶、肾素、血管紧张素、醛固酮减少。结论：心钠素可有效地纠正妊高征病人的病理生理变化，达到降压、利尿、消除尿蛋白的效果。近期、远期未发现对母婴有不良影响。Objective:To evaluate the clinical effect and mechanism of ANP on the therapy of patients with PIH.Methods:60 patients with PIH were treated with ANP and 30 other patients with PIH were treated with magnesium sulfate.Clinical symptoms and body signs were observed,and serum superoxidate dismutase(SOD)and vasoactive mediators such as ANP,renin,angiotensin and aldosterone were measured before and after treatment.No adverse effects on mothers and newborns was found.Results:After the intravenous infusion of ANP,the blood pressure of patients dedined;volume of urine increased;serum levels of SOD,renin,angiotensinⅡand aldosterone decreased significantly.Apgar score of newborns was not altered.Conclusion:ANP is able to correct the pathophysiological disorders happened in patients with PIH.This effect is characterized by reduction of urine protein,depression of blood pressure and receding of edema;ANP failed to prevent the occurrence of eclampsia and no adverse effect to mothers and neonates.

关 键 词：心钠素 妊娠高血压 综合征 药物疗法 

分 类 号：R714.246[医药卫生—妇产科学] R977.1[医药卫生—临床医学]