小剂量米索前列醇用于晚期妊娠引产的效果观察  

The Effect of 25 μg Misoprostol on Induction of Labor in Late Pregnancy

作　　者：王辉[1] 李蕾[1] 卜岚[1] 王虹[1] 乔桂红[1] 

机构地区：[1]北京安贞医院妇产科

出　　处：《中华妇产科杂志》1998年第8期469-471,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的观察２５μｇ米索前列醇对晚期妊娠引产的有效性和安全性。方法选择有引产指征、无引产及米索前列醇使用禁忌证的单胎、头位、胎膜完整的晚期妊娠妇女４８例，随机分为Ａ组（２７例，米索前列醇２５μｇ）和Ｂ组（２１例，米索前列醇５０μｇ）。间隔４～６小时重复给药，２４小时内最大剂量为２００μｇ。胎膜破裂或临产则停止用药。结果Ａ组与Ｂ组引产成功率分别为７７．８％、８１．０％。首次用药至临产时间分别为７６９．９±３５９．９分钟、８０７．４±４０５．２分钟，首次用药至阴道分娩时间分别为９７８．６±４６４．４分钟、９７７．５±４２１．４分钟，加用催产素引产者Ａ组４例、Ｂ组２例；分娩方式、新生儿体重，两组比较，差异均无显著性（Ｐ＞０．０５），但宫缩过强伴发胎心监护异常的发生率Ａ组低于Ｂ组。Objective To determine the efficacy and safety of 25 μg misoprostol for labor induction in the third trimester of pregnancy. Methods 48 term pregnant women with single pregnant、vertex present、 intact membrane were selected in study group. All case in study group indications for labor induction, without contraindication of labor induction and misoprostol. The 48 women were randomly assigned A(25 μg) and B(50 μg) misoprostol groups. Misoprostol was placed in the posterior vaginal fornix every 4 to 6 hours .The maximum dose in 24 hours is 200 μg. Misoprostol was not given after either spontaneous rupture of membrane or beginning of active labor. Result The sucesess rate of induction labor was groups 77.8%, 81.0% in group A and B, respectively. The average duration from administration of misoprostol to start of labor in two groups was 796.9±359.9 minutes and 807.4±405.2 minutes, respectively; the average duration from start of misoprostol use to vaginal delivery was 978.6±464.4 minutes, 977.5±421.4 minutes, respectively. The incidence of vaginal delivery had no statistics significant difference between two groups (P> 0.05). The incidence of hypertonic uterine contraction or hypertonic contractionchysystole with abnormal pattern of fetal monitoring in group A was lower than that of group B, but there was no significant difference (P>0.05). Conclusion 25 μg misoprostol is an efficient and safe dosage for labor induction in term pregnancy.

关 键 词：米索前列醇 妊娠末期 药物引产 小剂量 

分 类 号：R719.31[医药卫生—妇产科学] R984[医药卫生—临床医学]