93例泌尿系真菌感染菌群分布及药物敏感试验结果  

An analysis of species distribution and antifungal susceptibility of 93 strains of infecting urinary system epiphytes

作　　者：夏玲玲[1] 周仲松[1] 刘贵育[1] 李家斌[1] 余鑫之[1] 

机构地区：[1]安徽医科大学第一附属医院感染病科,合肥230022

出　　处：《安徽医学》2009年第8期897-899,共3页Anhui Medical Journal

摘　　要：目的了解近3年泌尿系统感染真菌的检出率、菌种分布及药物敏感试验结果,为临床合理使用抗真菌药物提供依据。方法中段尿真菌培养分离的菌株鉴定,采用ATB Fungus3纸片扩散法测定药敏性。结果共分离到真菌93株,其中白色念珠菌49株(52.7%)、光滑念珠菌27株(29.0%)、热带念珠菌13株(13.9%),它们对氟康唑的耐药率分别为16.7%、3.8%及23.1%;对伊曲康唑耐药率分别为21.1%、39.1%及33.3%;对氟胞嘧啶耐药率分别为37.8%、20.0%及15.4%;热带念珠菌对两性霉素B耐药率为23.1%,其他真菌对两性霉素B敏感。结论泌尿系感染真菌以白色念珠菌、光滑念珠菌及热带念珠菌为主,对三唑类药物敏感性较好,部分热带念珠菌对两性霉素B耐药。Objective To study and analyze the detected rate, distribution of fungal species and antifungal susceptibility of 93 strains of infecting urinary system epiphytes in the last three years to provide foundation for the reasonable clinical use of anti-epiphyte medicines. Methods The epiphytes isolated from epiphyte culture of midstream urine were tested and their drug sensitivity was tested with ATB Fungus 3 diffusion method. Results Of 93 strains isolated in the experiment, 49 were Candida albicans, accounted for 52.7%; 27 were C. glabrata, accounted for 29.0%; and 13 were C.tropiclis, accounted for 13.9%. And their drug resistances to fluconazole were 16.7%, 3.8% and 23.1%, respectively, itraconazole were 21.1%, 39.1% and 33.3%, respectively, flucytosine were 37.8%, 20.0% and 15.4%, respectively. C.tropiclis resistances to amphotericin B were 23.1%, other tested epiphytes were sensitive to amphotericin B. Conclusion The majority of tested epiphytes are C. albicans, C. glabrata and C.tropiclis in our hospital epipbytic infections of urine system, which are comparatively sensitive to zole medicines. Some C.tropiclis is resistances to amphotericin B.

关 键 词：真菌 菌种分布 药物敏感 泌尿系统 

分 类 号：R446.5[医药卫生—诊断学] R691.3[医药卫生—临床医学]