PDMS表面修饰方法的研究进展  

Research Advances in PDMS Surface Modification

作　　者：郑小林[1] 张瑞强[1,2] 杨军[1] 金庆辉[2] 许蓉[1] 赵建龙[2] 

机构地区：[1]重庆大学生物工程学院,重庆400030 [2]中国科学院上海微系统与信息技术研究所,上海200050

出　　处：《材料导报》2009年第15期5-8,共4页Materials Reports

基　　金：国家自然科学基金(30500120;30770569);国家863项目(2006AA04Z343);上海市科委项目(0652nm016;0752nm021;06XD14037)

摘　　要：聚二甲基硅氧烷(Polydimethylsiloxane,PDMS)由于具有良好的光学和化学性能,以及加工简单、价格便宜等优点,已广泛应用于微流控芯片研究领域。但PDMS的高疏水性以及它对如DNA、蛋白质等生物大分子具有较强的表面吸附特性,限制了它的应用范围。目前,基本上都是通过修饰的方法来改善PDMS表面亲水性能。按照PDMS经处理后恢复疏水性的时间长短,将PDMS表面修饰的方法分为暂时性修饰方法和永久性修饰方法;也可以按照对PDMS处理的原理分为物理修饰方法、化学修饰方法以及将两者相结合使用的方法。总之,各种方法都有很广泛的应用,实际处理时,仍要考虑到实验条件等因素的限制。概述了目前常用的几种针对PDMS表面修饰的方法,包括它们的基本原理、修饰效果以及相关应用研究。Due to its excellent optical, chemical and fabricable properties, as well as its low cost, PDMS has become one of the most widely used materials in microfluidic research field. However, its high hydrophobility and strong surface adsorbility for biological macromolecules（such as DNA, protein, etc. ） limit its application. Commonly, surface modification of PDMS can overcome these defects and make some improvement on hydrophilicity. According to the hydrophobility recovering time of PDMS, surface modification methods can be divided into transient method or permanent modification methods; considering the processing principles, surface modification methods can be divided into physical, chemical modification or combining both of them. Though various methods are all widely applied, practically, it all depends on the experimental limits and conditions. In the paper, several main modified methods are reviewed, including their fundamental principles, effect and some relative application.

关 键 词：PDMS 表面修饰 微流控芯片 

分 类 号：O634.41[理学—高分子化学] TQ641[理学—化学]