气囊扩张与A型肉毒杆菌毒素注射序贯联合治疗贲门失弛缓症38例临床护理  

Clinical nursing care in the treatment of 38 patients with esophageal achalasia by applying balloon dilation combined with intrasphincteric injection of botulinum toxin-A

作　　者：卜令秀[1] 章海霞[2] 邵先玉[1] 杨正武[1] 马立兴[1] 

机构地区：[1]泰山医学院附属医院,山东泰安271000 [2]泰安市第一人民医院

出　　处：《齐鲁护理杂志（下半月刊）（外科护理）》2009年第7期13-15,共3页Journal of Qilu Nursing

摘　　要：目的:探讨哑铃型气囊扩张器扩张序贯联合A型肉毒杆菌毒素注射治疗贲门失弛缓症(AC)的近、远期疗效和护理方法。方法:对38例AC患者应用哑铃型气囊扩张器扩张1周后注射A型肉毒杆菌毒素100 U,并进行精心护理。结果:本组治疗后1、3、6、12、24个月有效率分别为100.0%、94.7%、89.5%、81.6%、55.3%。治疗后1周食管下端括约肌压力(LESP)、食管下端括约肌松弛率(LESRR)与治疗前比较有极显著性差异(P<0.01),治疗后24个月LESRR与治疗后1周比较有显著性差异(P<0.05)。结论:哑铃型气囊扩张器扩张序贯联合肌内注射A型肉毒杆菌毒素治疗技术可靠,安全性高,采取适宜的护理措施,可取得满意的临床疗效,且降低并发症发生率。Objective ： To explore the short - term and long - term curative effect of dumbbell - shape balloon dilation combined with intrasphineteric injection of botulinum toxin - A and nusring methods in the treatment of esophageal aehalasia. Methods： Dumbbell -shape balloon dilation was applied to 38 patients with esophageal aehalasia for one week ,and then the patients were given injection of 100 U botulinum toxin - A and careful nursing care was carried out at the same time. Results ： The treatment efficiency in 1, 3, 6, 12 and 24 months were 100.0%, 94.7%, 89.5%, 81.6%, 55.3% respectively. After treatment for one week, the significant differences were found in the comparison of lower esophageal sphincter pressure （ LESP） and lower esophageal sphincter relaxation rate （ LESRR） before and after treatment （ P 〈0. 01 ） ; the comparison of LESRR was significantly different after treatment for 24 months and for one week （ P 〈 0. 05 ）. Conclusion： The therapeutic technique of balloon dilation combined with intrasphineterie injection of botulinum toxin - A is reliable and safe. The appropriate nursing care can get a satisfactory clinical efficacy and reduce the incidence of complications.

关 键 词：贲门失弛缓症 哑铃型气囊扩张器 肉毒杆菌毒素 护理 

分 类 号：R473.6[医药卫生—护理学]