益气养阴方对子宫颈癌细胞MMP2表达的影响  

Effect of Reinforcing Qi and Nourishing Yin on MMP2 Expression in Cervical Carcinoma Cells

作　　者：张栋 孙静[2] 

机构地区：[1]青岛市海慈医疗集团,山东青岛266033 [2]山东中医药大学,山东济南250355

出　　处：《中华中医药学刊》2009年第8期1709-1711,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：山东省中医药管理局资助项目(2005-115)

摘　　要：目的:研究益气养阴方对子宫颈癌细胞基质金属蛋白酶2(MMP2)表达的效应。方法:复制小鼠子宫颈癌U14自发性转移模型,应用免疫组织化学及其组织形态学定量分析方法对MMP2在子宫颈癌中的表达进行研究。结果:益气养阴方组的肺部转移结节较模型组明显减少,并且明显改善化疗对机体的免疫损伤。结论:益气养阴方对肿瘤血管形成有明显抑制作用,降低MMP2的表达可能是其抑制肿瘤血管形成的主要机制之一。Objective ：To study the role of Reinforcing Qi and Nourishing Yin on matrix metalloproteinase 2 （MMP2） in cervical carcinoma cells. Methods ： Cervical carcinoma U14 spontaneous metastasis model was adopted. The expression of MMP2 in cervical carcinoma was investigated by immunohistochemical and morphological analytics methods. Results：The expression of MMP2 in Reinforcing Qi and Nourishing Yin group was lower than the control group（ P 〈 0. 01 ）. Conclusion：Reinforeing Qi and Nourishing Yin has inhibitory effects on angiogenesis. Its mechanism may be associated with the down - regulating of MMP2 expression.

关 键 词：益气养阴方 基质金属蛋白酶2 免疫组化 

分 类 号：R285.5[医药卫生—中药学]