针刺对急性脑梗死患者凝血和纤溶系统的影响  

Influences of Acupuncture on the Contents of Blood Plasma t-PA PAI-1 D-Dimer and Fib in Patients with Acute Cerebral Infarction

作　　者：黄伟[1] 吴绪平[1] 丁昀[2] 罗惠平[1] 孙国杰[1] 吴洪阳[1] 

机构地区：[1]湖北中医学院,湖北武汉430061 [2]孝感市中心医院,湖北孝感432100

出　　处：《中华中医药学刊》2009年第8期1713-1715,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：湖北省教育厅科学研究计划资助项目(D200516006)

摘　　要：目的:探讨针刺对急性脑梗死患者凝血和纤溶系统的影响。方法:93例急性脑梗死患者分为针刺治疗组55例,西药对照组38例。针刺治疗组采用针刺百会、水沟进行治疗,西药对照组采用川芎嗪注射液及脑复康注射液进行治疗,检测两组患者治疗前后血浆组织型纤溶酶原激活物(t-PA)、纤溶酶原激活物抑制物-1(PAI-1)、D-二聚体(D-D)及纤维蛋白原(F ib)含量。另选20例健康体检者作为正常对照组,检测血浆t-PA、PAI-1、D-二聚体及F ib含量。结果:脑梗死患者治疗前血浆t-PA、PAI-1、D-二聚体及F ib含量显著增高,与正常组比较,有极显著性差异(P<0.01);治疗后两组血浆t-PA、PAI-1、D-二聚体及F ib含量均呈下降趋势,但针刺治疗组下降更明显,且接近正常值水平,与治疗前比较,有极显著性差异(P<0.01),与西药对照组比较,有显著性差异(P<0.05)。结论:针刺能显著降低急性脑梗死患者血浆t-PA、PAI-1、D-二聚体及F ib含量,调节机体凝血纤溶系统活性。Objective： To observe the effect of acupuncture on t - PA, PAI- 1, D -dimer and fibrinogen in patients with acute cerebral infarction. Methods：Nninty-three patients were randomly divided into two group. Acupuncture group（ n =55 ）were treated by acupuncturing on Baihui and Shtfignu points. Control group（ n = 38） were treated with ligustrazine and Piracetam parenteral solution by intravenous injection. The contents of blood plasma t - PA, PAI- 1, D - Dimer and Fib were detected in two groups on pretherapy and post-treatment. Twenty health medical examination persons were selected as normal group and contents of blood plasma t - PA, PAI- 1, D - Dimer and Fib were detected. Results ： The contents of blood plasma t - PA, PAI- 1, D - Dimer and Fib in patients were increased significantly （P 〈0.01 ）. After treatment, the contents of blood plasma t - PA, PAI- 1, D - Dimer and Fib were declined in two groups. Compared with control grouop,The contents of blood plasma t- PA,PAI -1 ,D -Dimer and Fib in acupuncture group were declined obviously, there were significantly difference between two groups （ P 〈 0. 05 ）. Conclusion： Acupuncture can effectively decrease the contents of t - PA,PAI - 1 ,D - timer and fibrinogen in patients with acute cerebral infarction and improve the abnormal of fibrinolysis.

关 键 词：急性脑梗死 针刺疗法 组织型纤溶酶原激活物 纤溶酶原激活物抑制物-1 D-二聚体 纤维蛋白原 

分 类 号：R246[医药卫生—针灸推拿学]