庆大霉素与肝素分离封管法预防中心静脉导管相关性感染的临床观察  

Preventing Central Venous Catheter-related Infection Using Catheter-sealing Separately with Gentamicin and Heparin:A Clinical Observation

作　　者：万翠娥 袁慧忠 李树春[1] 

机构地区：[1]黄石市第二医院肾内科,湖北黄石435002

出　　处：《中华医院感染学杂志》2009年第16期2112-2113,共2页Chinese Journal of Nosocomiology

摘　　要：目的观察庆大霉素与肝素分离封管预防中心静脉导管相关性感染的临床效果,探讨一种新的中心静脉置管封管方法。方法选择136例次临时性中心静脉置管的血液透析患者,随机分为3组,分别采用不同的方法封管;A组46例(庆大霉素与肝素分离封管组)、B组45例(庆大霉素与肝素混合封管组)和C组45例(肝素组),监测感染等情况。结果A组导管相关感染率及导管内感染率与B组间差异无统计学意义(P>0.05),但均比C组明显降低(6.5%、4.4%比22.2%,P<0.05,4.3%、2.2%比17.8%,P<0.05)。结论庆大霉素与肝素分离封管能明显降低中心静脉导管内感染的发生率,不增加其并发症的发生率;是一种安全有效的封管方法。OBJECTIVE To explore and evaluate the efficacy of preventing the central venous catheter-related infection using catheter sealing separately with gentamicin and heparin. METHODS One hundred and thirty six hemodialysis patients with temporary indwelling central venous catheters were enrolled in this study, and randomly assigned into 3 groups： Group A （catheter-sealing separately with gentamicin and heparin, n= 46）, Group B （catheter-sealing with gentamicin mixted heparin, n=45） and Group C （catheter-sealing with heparin, n=45）. Complications such as infection were monitored. RESULTS Rate of catheter-related infection and intravenous catheter infection were without significant difference between Groups A and B, but were obviously lower than that in Group C （6.5% and 4.4% vs 22.2%, P〈0. 05, 4.3% and 2.2% vs 17.8%, P〈0.05）. CONCLUSIONS Catheter-sealing separately with gentamicin and heparin is effective to reduce the rate of indwelling intravenous catheter infection and does not increase the incidence of complications. It is a safe and reliable catheter-sealing method.

关 键 词：庆大霉素 肝素 导管 封管 导管相关性感染 

分 类 号：R181.32[医药卫生—流行病学]