鼠脑射频损伤区神经修复的实验研究  

Research of Repairment on Radiofrequency Leion in rat brain

作　　者：宫崧峰[1] 高永中[1] 李维平[1] 蒋太鹏[1] 丁建军[1] 付友增[1] 

机构地区：[1]广东省深圳市第二人民医院神经外科,518038

出　　处：《中国误诊学杂志》2009年第24期5805-5807,共3页Chinese Journal of Misdiagnostics

摘　　要：目的:研究鼠脑射频性损伤后神经胶质纤维酸性蛋白(GFAP)、增生细胞核抗原(PCNA)的变化规律,进一步探讨脑外伤后神经修复的机制,为进一步治疗颅脑外伤作前期探索。方法:建立鼠脑射频损伤动物模型,分别研究损伤后的不同时段GFAP阳性、PCNA阳性、及二者均阳性的细胞。结果:总结GFAP阳性、PCNA阳性细胞的特点;GFAP阳性细胞、PCNA阳性的分布范围;GFAP阳性细胞的峰值远远大于PCNA阳性细胞的峰值;且二者均阳性的细胞数量极少。结论:颅脑损伤后修复主要依靠GFAP阳性细胞为主的胶质细胞肥大来完成。Objectives：To investigae the principle of GFAP and（or） PCNA positive cells in radiofrequency lesion of rat brain,and discuss the mechanisms of neuron repairment of brain injury,and to explore a better way for therapy brain injury. Methods ：Establish rat brain injury model ,and immunohistochemistrical stain to show GFAP and/or PCNA positive cells ,at different time point after injury. Results ：The changing curves of GFAP positive cells and PCNA positive cells were found,and their distributional range were also found;the density of GFAP positive cells are much more than that of PCNA positive cells ;and the cells of both GFAP positive and PCNA positive are rare. Conclusion ：The repairment of brain injury mainly depend on glial hypertrophy which GFAP are positive ,and may cause glial scar formation.

关 键 词：脑损伤/病理生理学 神经再生 动物 鼠科 

分 类 号：R651.15[医药卫生—外科学]