带有损伤修复机制的骨重建模型  

Bone Remodelling Model Including Mechanism of Damage and Repair

作　　者：王超[1] 张春秋[1] 武汉[2] 董心[3] 朱伟民[3] 刘海英[1] 

机构地区：[1]天津理工大学机械工程学院,天津300191 [2]吉林大学中日联谊医院,长春130033 [3]吉林大学机械科学与工程学院工程力学系,长春130025

出　　处：《生物医学工程学杂志》2009年第4期771-775,779,共6页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30772209;30570451);吉林省科技发展基金资助项目(20070540)

摘　　要：从力学角度讲,骨重建的作用一是适应力学环境,二是修复微裂纹。为了更全面地描述这种骨重建过程,我们提出了具有骨内损伤修复生理意义的骨重建模型。此模型基于基本多细胞单位,考虑到骨细胞对力学激励响应,不仅体现出微损伤受局部应力和骨密度影响呈随机发生,而且加入破骨细胞吸收后由成骨细胞修复这一生物学过程。研究中采用二维松质骨有限元模型为初始结构,预测了10个模拟年内骨微观结构、材料属性和力学性能的发展变化。结果发现:①松质骨在重建前期变化显著而后期趋于平稳;②松质骨的抗压能力远优于抗拉能力。From the visual angle of mechanics, bone remodelling plays an important role in adapting to load environment and repairing microcracks. In order to describe the process of bone remodelling explicitly, we introduced a bone remodelling model representing the biological features of damage/repair in bone. Based on Basic Multicellular Units （BMUs）, the model embodies not only the mechano-transduction of osteocytes＇ response to mechanical stimuli, but also the biological process of the randomly ocurring microcracks that are resorbed by osteoclasts and then refilled by osteoblasts. A 2-D trabecular bone finite element model was used as an initial configuration in the research. The developments in bone microstructure and material properties have been monitored in the course of 10 simulated years. The conclusions are.. ①Initially, trabecular bone changes prominently, but it tends to be stable later on; ② The material properties of trabecular bone in compression are much better than in tension.

关 键 词：骨重建 力学调控 损伤-修复 基本多细胞单位 数值模型 

分 类 号：R318.01[医药卫生—生物医学工程]