男性非骨质疏松患者体重指数对腰椎骨量的影响  

Effect of Body Mass Index on Bone Mass of Lumbar Spine of Male Patients with Ostealgia and Arthralgia but without Osteoporosis

作　　者：张金龙[1] 罗庆禄[1] 何成奇[1] 杨霖[1] 何红晨[1] 伍援朝[1] 谢薇[1] 熊恩富 

机构地区：[1]四川大学华西医院康复医学科,成都610041

出　　处：《生物医学工程学杂志》2009年第4期852-855,860,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30672215)

摘　　要：探讨非骨质疏松男性体重指数(Body mass index,BMI)与腰椎骨密度(Bone mineral density,BMD)、骨矿含量(Bone mineral content,BMC)之间的相关性,明确体重指数对人体腰椎BMD、BMC的影响。对2003.8～2005.12因骨关节疼痛在四川大学华西医院就诊并经双能X线骨密度仪检测,骨密度<-2.5SD的838例男性患者,计算BMI(Kg/m2)并分组:BMI≥23为第1组(该组按BMI≥29为A组46人、25≤BMI<28.9为B组201人、23≤BMI<24.9为C组193人);18.5<BMI<22.9为第2组311人;BMI≤18.5为第3组68人,应用SPSS13.0统计软件进行统计分析。(1)1、2、3组间比较,L2-L4BMD、平均BMD、aBMC比较均为3组>2组>1组,差异显著有统计学意义(P<0.05或P<0.01);L3和L4BMC、aBMC及L2aBMC均为3组>2组>1组,差异显著(P<0.01),而L2BMC为1组>3组>2组,无统计学意义(P>0.05);T值组间比较无统计学意义(P>0.05)。(2)1组中,A、B、C三组内比较,L2-L4BMD、平均BMD均为C组>B组>A组,差异显著,有统计学意义(P<0.05或P<0.01);L3和L4BMC、aBMC及L2aBMC均为C组>B组>A组,差异显著(P<0.01),而L2BMC为A组>C组>B组,差异无统计学意义(P>0.05);T值各组内比较无统计学意义(P>0.05)。(3)BMI与平均BMD呈负相关性(P<0.01,r=-0.189)。非骨质疏松男性其体重指数升高可降低腰椎平均骨密度,且肥胖越明显者,其腰椎平均骨密度下降越明显,L3和L4骨密度、骨矿含量、总骨矿含量下降幅度可能大于L2。For the purpose of identifying the effect of body mass index on bone mineral density, an investigation was made in regard to the relationship between body mass index （BMI）, bone mineral density（BMD） and bone mineral eontent（BMC） of lumbar vertebrals of men without osteoporosis. 838 male patients were diagnosed and treated in West China Hospital of Sichuan University because of ostealgia and arthralgia from Aug. 2003 to Dec. 2005. They were examined by dual-energy X-ray absorptiometry, their L2-L4 bone mineral density being 〈- 2. 5SD. Then they were graded by body mass index（Kg/m2）Elst group BMI≥23, 454 cases（Group A BMI≥29,46 eases; GroupB 25≤BMI〈28.9, 201 eases; Group C 23≤BMI〈24. 9,193 cases）; 2^nd group 18.5〈BMI〈22.9, 311cases;3^rd group BMI≤18. 5,68 cases]. The relationships between BMI and BMD of lumbar spine were analyzed using SPSS13.0. The results revealed their positions in series： （1）Among Groups 1n 3, BMD, average BMD and aBMC of L2- L4 being 3^rd group〉-2^nd group〉 1^st group, the differencs are statistically significant（P〈0. 05 or P〈 0.01）; BMC,aBMC of L2 and L4 and aBMC of 1.2 being 3^rd group〉2^nd grou：〉1^st group, the differences are significant（P〈0. 01） ;besides BMC of L2 and T-score,the differencs among three groups are not statistically significant（P 〉0. 05）;（2）Among the 1^st group, BMD and average BMD of L2-L4 being Group C〉Group B〉Group A,the differencs are significant（P〈0. 05 or P〈0. 01）; BMC,aBMC of L3 and L4 being Group C〉Group B〉Group A,the differences among the three groups are significant （P〈0.05 or P〈0.01） ; BMC,aBMC of L3 and L4 and aBMC of L2 being Group C〉Group B〉Group A,the differences are significant; besides BMC of L2 and T-score, the differences among three groups are not significant（P〉0. 05）; （3）BMI correlated negatively（P〈0.01 ,r= -0. 189）to the average BMD of lumbar spine. The average BMD of lumbar spine decreases when BMI increases in males without oste

关 键 词：非骨质疏松 体重指数 骨密度 骨矿含量 

分 类 号：R580[医药卫生—内分泌]