关于骨髓间充质干/祖细胞群中RS细胞亚群的研究进展  

A Review of Studies on a Subset of Rapidly Self-renewing Marrow Stromal Cells

作　　者：胡诗宇[1] 杨柳[1] 孙海英[1] 

机构地区：[1]上海交通大学药学院,上海200240

出　　处：《生物医学工程学杂志》2009年第4期890-894,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金青年科学基金资助项目(30600332)

摘　　要：易于取材并具有多向分化潜能的骨髓间充质干/祖细胞已成为细胞/基因治疗及组织工程的优选种子细胞之一,探索获取具有更强自我更新能力及多向分化潜能均质细胞群的方法将进一步推进并完善其临床应用。Colter等发现在骨髓间充质干/祖细胞克隆群中除了纺锤型及扁平细胞外,还含有一种非常小的圆形细胞(RS细胞)。该细胞与上述两类细胞相比具有更强的自我更新能力及多向分化潜能,并且表达与成熟细胞不同的特殊蛋白和表面抗原,提示该类细胞用于体内长期移植或细胞治疗更具明显优势。本文围绕RS细胞的研究进展做一回顾,并对其未来的应用前景寄予展望。A series of studies have demonstrated that bone marrow mesenchymal stem cells （MSCs） are attractive candidates for cell and gene therapies, because they are readily obtained and multipotentially differentiated. Then homogeneous MSC cultures in vitro with more rapidly self-renewing ability and multipotential differentiation will accelerate and improve their progress in clinical application. Colter et al. found that early colonies contain a third kind of cell., very small round cells that rapidly self-renew, besides spindle-shaped ceils and large flat cells, called RS cells. RS cells are characterized by their extremely small size, rapid rate of replication, and enhanced potential for multilineage differentiation. Moreover, they can be distinguished from more mature cells in the same cultures by a series of surface epitopes and expressed proteins. Therefore, the results raise the possibility that RS ceils may have the greatest potential for long-term engraftment and differentiation in vivo.

关 键 词：骨髓间充质干细胞 异质性 RS细胞 移植 细胞和基因治疗 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]