脉络宁注射液治疗脑梗死的系统评价  

A Meta analysis on the effectiveness and safety of Mailuoning injection on cerebral infarction system

作　　者：石庆平[1] 丁峰[1] 朱锦秀[1] 程鹏[1] 许善初[1] 刘雁[1] 

机构地区：[1]蚌埠医学院第一附属医院药剂科

出　　处：《中国临床药理学与治疗学》2009年第6期650-654,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:系统评价脉络宁注射液治疗脑梗死的有效性和安全性。方法:应用国际Cochrane协作网系统方法评价脉络宁注射液治疗脑梗死的临床随机对照试验(RCT)。计算机检索Cochrane临床对照试验资料库,纳入脉络宁注射液治疗脑梗死的RCT。由两名评价者独立提取资料并进行质量评估。试验数据的统计分析采用Cochrane协作网提供的Rev Man 5.0.17.0软件。结果:最终纳入了13个RCT并对其疗效进行了Meta分析,表明脉络宁注射液治疗脑梗死与对照组相比,疗效差异有统计学意义[OR 4.01,95%CI(2.75,5.84),P<0.00001];均未报道脉络宁注射液引起的严重系统性不良反应。结论:现有临床证据表明,脉络宁注射液治疗脑梗死的有效性和安全性相比,疗效可能优于对照组,但不是肯定的结论。AIM： To evaluate the effectiveness and safety of Mailuoning injection on cerebral infarction system. METHODS： A systematic review of randomized controlled trials （RCT） of Mailuoning injection on cerebral infarction system was performed. Trials were identified by searching the Cochrane Library （ issue 12, 2008） , MEDL I NE （ 1966 - 2008） , BMBASE （ 1984 - 2008） and CNKI （ 1979 - 2008）. Two authors assessed the quality and reviewed the data independently. Statistical analysis was performed by using Rev Man 5.0. 17.0. RESULTS： Thirteen trials ranked high quality were included. Meta-analysis of the treat- ment of Mailuoning injection on cerebral infarction system showed there were no significant differences between Mailuoning injection and the control group [ OR 0.72, 95% CI 0.47 to 1.11 ）, P = 0.23 ]. No serious systematical adverse reaction was recorded in the two trails. CONCLUSION： Mailuoning injection is an more effective and safe regimen for the treatment of cerebral infarction system than control group probably, but not certain.

关 键 词：脉络宁注射液 META分析 脑梗死 随机对照试验 

分 类 号：R911[医药卫生—药学] R969