低剂量电离辐射诱导小鼠胚胎细胞对镉的交叉适应性  

LOW DOSE IONIZING RADIATION INDUCED CROSSADAPTATION TO CYTOGENETIC DAMAGE OF EMBRYONIC CELLS OF MICE CAUSED BY SUBSEQUENT CADMIUM

作　　者：芦春林[1] 阮明[1] 刘书逊 刘俊 

机构地区：[1]北京医科大学卫生毒理学教研室

出　　处：《北京医科大学学报》1998年第4期340-341,344,共3页Journal of Peking University(Health Sciences)

摘　　要：目的：了解低剂量电离辐射与镉之间是否存在交叉适应性反应。方法：孕第９天小鼠在整体条件下，全身受低剂量１、２、４、８ｃＧｙ６０Ｃｏγ射线照射，４ｈ后给致畸剂量镉４ｍｇ／ｋｇ，观察胚胎细胞染色体畸变率。结果：１、２、４、８ｃＧｙ６０Ｃｏγ射线，均能诱导胚胎细胞对镉４ｍｇ／ｋｇ的细胞遗传损伤的耐受性。ABSTRACT Objective: To explore if low dose ionizing radiation could induce crossadaptive response to cytogenetic damage in embryonic cells caused by subsequent cadmium chloride. Methods: The mice were wholebody irradiated with60Co γrays 1,2,4 and 8 cGy respectively on gestation d 9. 4 h after, the mice were injected CdCl2 solution according to Cd 4　mg/kg. Chromosome aberrations of embryonic cells of gestation d 10 were analysed. Results: 1,2,4 and 8 cGy60Co γrays induced resistance to cytogenetic damage of embryonic cells caused by subsequent Cd 4　mg/kg body weight. Conclusion: The results first demonstrated that low dose ionizing radiation can induce crossadaptive response to cytogenetic damage of embryonic cells caused by subsequent cadmium.

关 键 词：低剂量 电离辐射 胚胎细胞 铬 辐射效应 

分 类 号：Q691.5[生物学—生物物理学]