低剂量辐射诱导小鼠胸腺细胞凋亡及细胞周期进程的适应性反应  

ADAPTIVE RESPONSE OF THYMOCYTE APOPTOSIS AND CELL CYCLE PROGRESSION INDUCED BY LOW DOSE RADIATION

作　　者：龚守良[1] 刘淑春[1] 张迎春[1] 刘树铮[1] 

机构地区：[1]白求恩医科大学放射生物教研室

出　　处：《辐射研究与辐射工艺学报》1998年第3期150-152,共3页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金

摘　　要：应用流式细胞术观察７５ｍＧｙＸ射线诱导小鼠胸腺细胞凋亡及细胞周期进程的适应性反应。结果表明，１．５或２．０Ｇｙ全身照射后，小鼠胸腺细胞凋亡小体（ＴＡＢ）百分数明显增加，Ｓ期ＴＡＢ百分数明显减少，而Ｇ０／Ｇ１和Ｇ２＋Ｍ期ＴＡＢ百分数明显增加；当１．５或２．０Ｇｙ（攻击剂量，Ｄ２）照射前６ｈ给予７５ｍＧｙ（诱导剂量，Ｄ１）照射时，明显减轻Ｄ２对胸腺细胞凋亡及细胞周期进程的损伤作用。提示，低剂量辐射可诱导胸腺细胞凋亡及细胞周期进程的适应性反应。The adaptive response of thymocyte apoptosis and cell cycle progression induced by 75mGy X rays in mice were observed. The percentages of thymocyte apoptotic bodies (TAB) and cell cycle phase count were examined with flow cytometry. It was found that the percentages of TAB increased, the percentages of S phase cells decreased and the percentages of G 0/G 1 and G 2+M phase cells increased after whole body irradiation with 1.5 or 2.0Gy in mice, all were significant statistically, as compared with sham irradiation. When the mice were irradiated with 75mGy (inductive dose, D 1) 6h before 1.5 or 2.0Gy (challenge dose, D 2) exposure, the damage effects of D 2 on thymocyte apoptosis and cell cycle progression were obviously weaked. Low dose radiation may induce the adaptive response of thymocyte apoptosis and cell cycle progression.

关 键 词：低剂量辐射 细胞凋亡 细胞周期进程 动物 胸腺 

分 类 号：R811.5[医药卫生—放射医学] Q691[医药卫生—临床医学]