抗疲劳1号对游泳大鼠血液、肌肉和脑中ATP含量及血乳酸含量的影响  

Effect of antifatigue-1 on ATP of blood,brain and muscle and blood lactic acid in rat

作　　者：郭中钰[1] 祝世功[1] 徐琪[1] 李天舒[1] 王金国 吴景全 

机构地区：[1]白求恩医科大学病理生理教研室

出　　处：《中国病理生理杂志》1998年第4期385-388,共4页Chinese Journal of Pathophysiology

基　　金：吉林省科委资助

摘　　要：目的：观察抗疲劳１号（ＡＦ－１）对游泳运动大鼠血液ＡＴＰ和乳酸，以及脑和肌肉组织中ＡＴＰ含量的影响。方法：用生物发光法测定６组不同游泳强度大鼠血液和组织中ＡＴＰ含量；血乳酸含量变化用乳酸自动分析仪监测。结果：给药组大鼠游泳１０ｍｉｎ，血中ＡＴＰ含量明显高于对照组；血中乳酸含量明显低于对照组（Ｐ＜００１）。在游泳力竭鼠中，给药组血ＡＴＰ含量也较对照组高；而血乳酸含量较对照组低（Ｐ＜００５，Ｐ＜００１）。给药大鼠中，游泳１０ｍｉｎ组肌肉ＡＴＰ含量明显高于对照组（Ｐ＜００１）；游泳力竭组仍可保持在对照组水平（游泳时间不同）。给药鼠游泳１０ｍｉｎ和力竭两组脑组织中ＡＴＰ含量与未给药动物无明显差异，但未游泳组明显高于对照组。未游泳给药鼠肌肉中ＡＴＰ含量也明显高于对照组（Ｐ＜００５，Ｐ＜００１）。结论：抗疲劳１号具有抗疲劳功用，可能通过增加组织ＡＴＰ的生成和贮存，促进能量代谢，减少乳酸堆积。AIM:To study the effect of antifatigue-1(AF-1) on ATP in blood,brain,muscle and blood lactic acid in swimming rats.METHOD:The contents of ATP in tissue and blood of swimming rats were detected by bioluminescence method,and the contents of lactic acid were misured by lactic acid automatic analyser in six different exercise status groups of rats.RESULTS:The content of ATP in blood was higher and content of lactic acid was lower in treated rats with AF-1 than untreated rats in 10 min Xwimming group(P<001,P<001),as well as in exhaustive group (P<005 and P<001). The ATP in muscle was increased in 10 min swimming group and was unchanged in exhaustive group in AF-1 treated rats compared with untreated rats.There is no difference of brain ATP content among each swimming group,but a higher ATP was detected in AF-1 treated compared with untreated rats in non-swimming group. CONCLUSION: AF-1 promoted energy metabolism by increasing production and restoretion of ATP,and promote tissue utilizing of lactic acid.Therefor it increases the time and intensity of exercise.

关 键 词：腺苷三磷酸 乳酸盐类 运动疲劳 抗疲劳1号 

分 类 号：R872.702[医药卫生—运动医学]