某市农村居民类风湿性关节炎的危险因素分析  

Risk factor analysis of rheumatoid arthritis in a rural population

作　　者：张娜[1] 谭红专[1] 梁翠敏[1] 黄昕[1] 黄鹏[1] 张斯钰[1] 陈婷[1] 李林香[1] 赵鑫[1] 

机构地区：[1]中南大学公共卫生学院流行病与卫生统计学系,湖南省长沙市410078

出　　处：《中国组织工程研究与临床康复》2009年第33期6585-6588,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:分析影响类风湿性关节炎发病的危险因素。方法:采用多级整群抽样法,先从某市37个乡镇中随机抽取3个乡镇,对3个乡镇的全部常住居民进行类风湿性关节炎普查,类风湿性关节炎病例以县及县以上医院的诊断为准。在第一阶段调查发现的344名类风湿性关节炎患者中随机选择144人为病例组,同时选取在性别和年龄构成上与病例组相似的健康人群191人为对照组。调查项目主要包括性别、年龄、受教育程度、婚姻状况、感冒、鱼虾过敏、扁桃体切除、腮腺炎史、职业、劳动强度、外伤史、手术史、输血史、住房类型、居住环境潮湿、青春期前养猫或养狗、类风湿性关节炎或支气管哮喘或过敏性鼻炎家族史、口服避孕药、体质指数、吸烟、戒烟、饮酒、戒酒及饮茶等23个因素。结果:单因素分析结果显示,感冒、超重及肥胖、外伤史、支气管哮喘或过敏性鼻炎家族史、类风湿性关节炎家族史、饮茶、住平房和居住环境潮湿与类风湿性关节炎的关系有统计学意义。将单因素分析中的全部18个变量作为自变量,以是否患类风湿性关节炎作为应变量,采用后退法进行非条件Logistic回归分析,结果显示,感冒、支气管哮喘或过敏性鼻炎家族史、类风湿性关节炎家族史、饮茶、住平房、居住环境潮湿和超重及肥胖与类风湿性关节炎的联系有统计学意义。结论:农村居民的类风湿性关节炎主要与既往感冒、家族史、居住条件及生活习惯相关。OBJECTIVE： To explore the risk factors of rheumatoid arthritis. METHODS： With the method of multi-stage cluster sampling, three townships from 37 townships of a city randomly selected at first, and rheumatoid arthritis （RA） was investigated for all the three township residents. All the RA cases were determined based on the county or above hospital diagnosis. After that, 144 cases from the 344 diagnosed patients were randomly selected as the case group and 191 healthy people, which have the similar gender and age constitute to the patient group was served as the control group. Twenty-three variables were investigated in this study, which mainly include gender, age, educational level, marital status, common cold, allergy to fish and shrimp, tonsillectomy, mumps history, occupation, labor intensity, trauma history, surgical history, blood transfusion history, housing type, humid living environment, keeping cats or dogs before adolescent, family history of RA or bronchial asthma or allergic rhinitis, oral contraceptives, body mass index （BMI）, smoking, quit smoking, drinking, temperance, and drinking more tea and so on. RESULTS： Univariate analyses results showed that RA was significant statistically related to common cold, overweight and obesity, trauma history, family history of bronchial asthma or allergic rhinitis, family history of rheumatoid arthritis, drinking more tea, bungalow living and humid living environment. Then a multivariable unconditioned logistic regression analysis was adopt with the backward method, all the 18 variables mentioned in univariate analysis regarded as independent variables and the RA （yes or no） as the dependent variable. The results showed that RA was significant statistically associated with common cold, family history of bronchial asthma or allergic rhinitis, family history of rheumatoid arthritis, drinking more tea, bungalow living, humid living environment, overweight and obesity. CONCLUSION： The rheumatoid arthritis is primarily associated with common cold,

关 键 词：类风湿性关节炎 病例-对照 危险因素 

分 类 号：R593.22[医药卫生—内科学]