542例抗痫药副作用的前瞻性研究  

The Adverse Effects of Antiepileptics in 542 Epileptic Patients: A Prospective Study

作　　者：王学峰[1] 黄中文[1] 罗锦萍 

机构地区：[1]重庆医科大学附属第一医院神内科,400016

出　　处：《重庆医学》1998年第5期293-294,共2页Chongqing medicine

摘　　要：本文报告对542例癫痫病人进行抗病药毒副反应的前瞻性研究结果。在抗痫治疗的10年中，有95例（17.53％）病人出现不同的毒副反应。其中，苯妥英的毒副反应发生率为46.57％、卡马西平的发生率为9.62％、丙戌酸为7.10％、苯巴比妥为9.62％。毒副反应中最常见的是皮诊、共济失调、眼球震颤及胃肠道症状。有3例病人出现明显肝功能损伤。本文还讨论了毒副反应的发生规律及其对策。In a prospective study, we investigated the various adverse effects of Phenytoin (PHT),Carbamazepine (CBZ),Valproic acid(VPA)and Phenobarbital (PBT) in 542 epilePtic patients. The results showed that with followingup 10 years, 95 patients with epilepsy had various adverse effects. The incidence of adverse effects of PHT in 147 patients was 46. 57%,CBZ in 228 patients was 9. 62%, VPA in 170 patients was 7. 10% and PBT in 55 patients was 9. 62%.There were 3 patients with hepatic function impairn1ent. Skin rash, ataxia, nystagmus, anorexia, diarrhoea and nausea were the most common adverse reactions. The possible mechanism of the various adverse effects of antiepileptics is discussed.

关 键 词：癫痫 抗癫痫药 药物副作用 前瞻性研究 

分 类 号：R971.6[医药卫生—药品] R742.1[医药卫生—药学]