依那普利的血药浓度及其降压作用与血中血管紧张素Ⅱ、内皮素、心钠素变化的相关关系  

Enalapril in Essential Hypertension Patients:Relationship between Serum Drug Concentration and Hypertension and Other Relative Factors

作　　者：石湘芸[1] 田惠生[1] 赵云涛[1] 聂智群[1] 王亦流 孙忠实 张秀丽 

机构地区：[1]海军总医院心内科,北京100037 [2]海军总医院临床药理室,北京100037

出　　处：《标记免疫分析与临床》1998年第2期64-67,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：本文对11例原发性高血压（EH）患者顿服依那普利20mg后，动态观察血清依那普利拉浓度与血压、血浆血管紧张素Ⅱ（ATⅡ）、内皮素（ET）、心钠素（ANF）水平变化的关系，结果显示服药后血药浓度3h达峰值（177．2±3．68pgg/mL，4h开始下降（160.6±3．48pg/mL），7h降至最低（136．1±4．46pg／mL）；血压效应在1h开始起效，3h最明显，4～7h维持在有效水平；2、4、6h血浆AT,Ⅱ、ET和ANF水平逐渐下降，与治疗前比较有显著差异（P＜0．05～0．01），血药浓度与血压效应的变化一致，血药浓度与血浆ATⅡ水平之间呈非线性关系。Serum levels of enalaprilat, angiotensin Ⅱ (AT Ⅱ), endothelin(ET), atrial natriuretic factor (ANF) and blood pressure were monitored in Ⅱ cases with essential hypertension after taking enalapril 20 mg orally. The results indicated that the serum drug concentration reached the peak in 3 hours, began to decline at 4 hours, decreased to the lowest at 7 hurs. The blood pressure began to decline in 1 hour, reached the lowest level at 3 hours, maintained a plateau from 4 to 7 hours. Plasma AT Ⅱ, ET, ANF levels also droped markedly at 2, 4, 6 hours. The change. of serum drug concentration was concurrent with that of blood pressure. The non - linear relationship was shown between serum drug concentration and plasma AT Ⅱ level.

关 键 词：依那普利 药理学 血管紧张素 内皮素 心钠素 

分 类 号：R972.4[医药卫生—药品]